Biofilm Formation, Structural and Microbiological Characterization of Endotracheal Tube Biofilm, Ventilator-associated Pneumonia (VAP)
Conditions
Brief summary
Ventilator-associated pneumonia (VAP) remains the most frequent healthcare-associated infection (HAI) in the intensive care unit (ICU) and one of the most critical risk factors associated with both significant morbidity as well as mortality. Although VAP treatment relies on early and appropriate antimicrobial therapy, several preventive measures have been described in the literature in order to limit its incidence and clinical impact in the ICU. Among these, preventing biofilm formation on the inner surface of the endotracheal tube appears to hold promise. Yet there is a lack of clinical relevant data documenting a causal relation between biofilm formation and VAP. Designed to overcome this critical limitation, the BIOPAVIR study intends to provide a better structural and microbiological characterization of endotracheal tube biofilm in critically ill patients at increased risk for the development of VAP in ICU during COVID-19 pandemic.
Interventions
BIOLOGICALmicrobiological characterization
microbiological characterization of endotracheal tube biofilm
Sponsors
Centre Hospitalier Universitaire Dijon
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patient \> 18 years of age with mechanical ventilation for \>2 calendar days
Exclusion criteria
* inability to collect or dispatch the endotracheal tube for proper characterization within 24 hours post-extubation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Development of Ventilator-associated pneumonia (VAP) | Immediately after extubation of the patient | Provide a better understanding of the correlation between structural and microbiological characterization of endotracheal tube biofilm in critically ill patients and increased risk for the development of VAP in ICU during COVID-19 pandemic. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Development of other VAP, healthcare-associated infection (HAI) or mortality | Immediately after extubation of the patient | Provide a better understanding of the correlation between structural and microbiological characterization of endotracheal tube biofilm in critically ill patients and increased risk for the development of other VAP, healthcare-associated infection (HAI) or mortality in ICU during COVID-19 pandemic. |
Countries
France
Outcome results
None listed