Carbon Monoxide Poisoning
Conditions
Keywords
carbon monoxide poisoning, neurological sequelae
Brief summary
The purpose of this study is to access the clinical characteristics and risk factors for neurological sequelae after acute carbon monoxide poisoning.
Detailed description
After being informed about the study and potential risks, patients meet the inclusion criteria would be given informed consent and entry the study. The data will be collected according to self-designed questionnaire, including :1) The baseline characteristics: would be recorded 6 hours after patients presentation;2) Patients' self evaluation for discomfort symptoms: would be recorded at day 0, week 1, 3 and 6, month 6 and 12；3) Neurological function: would be recorded at day 0, week 6, month 6 and 12.
Interventions
OTHERNo intervention
No intervention will be given
Sponsors
The First Hospital of Jilin University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients present within 12 hours after acute carbon monoxide poisoning; * age older than 16 years.
Exclusion criteria
* pregnant women； * patients receive oxygen therapy before presentation; * have history of acute carbon monoxide poisoning within 1 year; * have been diagnosed any of the following disease: Parkinson disease; cognitive disorder, psychiatric disorders, sequelae of cerebral infarction or hemorrhage, chronic kidney disease and receive hemodialysis, congestive heart failure ( NYHA class III-IV)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes of self-evaluation of discomfort symptoms scale at 12 months | Changes of score from baseline to 12 months | This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome |
| Changes of self-evaluation of discomfort symptoms scale at 6 weeks | Changes of score from baseline to 6 weeks | This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome |
| Changes of self-evaluation of discomfort symptoms scale at 6 months | Changes of score from baseline to 6 months | This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome |
| Changes of Activity of Daily Living (ADL) score at 6 months | Changes of score from baseline to 6 months | Score ranges from 0 to 80, a higher score means a worse outcome. |
| Changes of Activity of Daily Living (ADL) score at 12 months | Changes of score from baseline to 12 months | Score ranges from 0 to 80, a higher score means a worse outcome. |
| Changes of Mini-mental State Examination (MMSE) score at 6 weeks | Changes of score from baseline to 6 weeks | Score ranges from 0 to 30, a lower score means a worse outcome. |
| Changes of Mini-mental State Examination (MMSE) score at 6 months | Changes of score from baseline to 6 months | Score ranges from 0 to 30, a lower score means a worse outcome. |
| Changes of Mini-mental State Examination (MMSE) score at 12 months | Changes of score from baseline to 12 months | Score ranges from 0 to 30, a lower score means a worse outcome. |
| Changes of Montreal cognitive assessment (MoCA）score at 6 weeks | Changes of score from baseline to 6 weeks | Score ranges from 0 to 30, a lower score means a worse outcome. |
| Changes of Montreal cognitive assessment (MoCA）score at 6 months | Changes of score from baseline to 6 months | Score ranges from 0 to 30, a lower score means a worse outcome. |
| Changes of Hamilton Anxiety Scale (HAMA) score at 6 months | Changes of score from baseline to 6 months | Score ranges from 0 to 56, a higher score means a worse outcome. |
| Changes of Hamilton Anxiety Scale (HAMA) score at 12 months | Changes of score from baseline to 12 months | Score ranges from 0 to 56, a higher score means a worse outcome. |
| Changes of Activity of Daily Living (ADL) score at 6 weeks | Changes of score from baseline to 6 weeks | Score ranges from 0 to 80, a higher score means a worse outcome. |
| Changes of Montreal cognitive assessment (MoCA）score at 12 months | Changes of score from baseline to 12 months | Score ranges from 0 to 30, a lower score means a worse outcome. |
| Changes of Hamilton Depression Scale(HAMD) score at 6 weeks | Changes of score from baseline to 6 weeks | Score ranges from 0 to 54, a higher score means a worse outcome. |
| Changes of Hamilton Depression Scale(HAMD) score at 6 months | Changes of score from baseline to 6 months | Score ranges from 0 to 54, a higher score means a worse outcome. |
| Changes of Hamilton Depression Scale(HAMD) score at 12 months | Changes of score from baseline to 12 months | Score ranges from 0 to 54, a higher score means a worse outcome. |
| Changes of Hamilton Anxiety Scale (HAMA) score at 6 weeks | Changes of score from baseline to 6 weeks | Score ranges from 0 to 56, a higher score means a worse outcome. |
| Changes of self-evaluation of discomfort symptoms scale at 1 week | Changes of score from baseline to 1 week | This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome |
| Changes of self-evaluation of discomfort symptoms scale at 3 weeks | Changes of score from baseline to 3 weeks | This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rates of accidental injury | through study completion, an average of 1 year | Accidental injuries may include accidental fall, fracture, traffic accident etc. A patient develops any of the former during following up would be record as 1 event. |
| Rates of cardiovascular and cerebrovascular events | through study completion, an average of 1 year | Cardiovascular and cerebrovascular events includes：cardiac arrest, myocardial infarction, cerebral hemorrhage, and cerebral infarction. A patient develops any of the former diseases during following up would be record as 1 event. |
Countries
China
Contacts
Primary ContactNing Dong, M.D.
Outcome results
None listed