Antihypertensive Drugs in ICU
Conditions
Keywords
intensive care, antihypertensive drugs
Brief summary
Multicenter, prospective and observational study of practices and impacts of the use of antihypertensive therapies in intensive medicine and intensive care
Detailed description
Multicenter, prospective observational cohort study on 200 patients, by doctor's questionnaire on the prescription of antihypertensive drugs in intensive care, follow-up over 72 hours of the prescription.
Interventions
OTHERInventory of prescribing habits and detect any differences in efficacy and tolerance of antihypertensive drugs
* Time to monitor blood pressure values in target targets * Need for administration of another antihypertensive drug * Disappearance of organ failure attributable to hypertension * Weaning from an extra-renal purification * Weaning from mechanical ventilation * Improved kidney function * Iatrogenic hypotension * Need for suspension of treatment * Other side effect
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Adult patient * Admitted to an intensive care unit * Patient having presented a state of circulatory shock, defined by the need for continuous administration of a vasopressive amine for at least one hour, among: Noradrenaline, Adrenaline * In whom the introduction of drug treatment for antihypertensive purposes is decided
Exclusion criteria
* Patient admitted to intensive care for a hypertensive emergency (hypertensive surge or malignant arterial hypertension leading to organ dysfunction * Patient who has already received at least one anti-hypertensive drug during his stay in intensive care * Cerebro-injured patient, proven or suspected cerebral edema, head trauma \<1 month, decrease in cerebral perfusion measured * Proven or suspected active bleeding * Patient refusal of participation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Make an inventory of prescribing habits and detect any differences in efficacy and tolerance of antihypertensive drugs in intensive care and intensive care settings | 60 days after inclusion | Description in number of drugs |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Search for efficiency differences between the different molecules | 60 days after inclusion | Time to control blood pressure values in the targeted targets |
| Search for differences in side effects between the different molecules | 60 days after inclusion | Iatrogenic hypotension |
Countries
France
Contacts
Primary ContactGAUDRY Stephane
Outcome results
None listed