Tunis Military Hospital Staff Vaccinated Against Covid 19
Conditions
Brief summary
The purpose of the research is to evaluate kinetic after vaccination to the COVID-19 coronavirus by measurements of specific and neutralizant antibodies for spike antigenic sequences . This work will allow us to follow the efficacy and tolerance of the vaccine over a year, to evaluate the antibody profile, their kinetics, the fraction of neutralising antibodies and will also allow us to understand the attitudes to be taken to ensure the best protection for our staff
Detailed description
Our objective is to follow the hospital staff after vaccination, for this we will include two groups of participants: G1: vaccinated staff who did not contract the virus (at the date of vaccination) and who had a serology \<0 at least at D7 of the date of vaccination dose 1 (known serological value) G2: vaccinated personnel who have contracted the virus with a PCR + and who have positive serology at least at D7 of the date of vaccination (known serological value)
Interventions
OTHERBlood sampling (4 per year)
Blood sampling (4 per year)
Sponsors
General Administration of Military Health, Tunisia
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Inclusion criteria
RB-approved informed consent, age 18 years or older, male or female, anyone considering COVID-19 vaccination or anyone that has received COVID-19 vaccination. Subjects can enroll at anytime after vaccination even though they may not have enrolled before vaccination. Sampling Frequency and timing: Up to 8 total samples in 12 months -
Exclusion criteria
Exclusion: Failure to provide informed consent \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vaccine effectiveness | 1 year | Vaccine effectiveness as measured by the number of positive PCRs in one year |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the tolerance of the vaccine | 1 year | post-vaccination adverse event |
Countries
Tunisia
Outcome results
None listed