Liver Diseases
Conditions
Brief summary
The aim of the study is to investigate the effect of personalised exercise interventions in liver transplant candidates, aiming to prevent or limit sarcopenia and frailty, as well as improving their cardiorespiratory health.
Interventions
BEHAVIORALPersonalised exercise
Personalised exercise intervention including aerobic and resistance training
Sponsors
Aristotle University Of Thessaloniki
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Liver transplant candidates, accepted in the waiting list of the Surgical Department of Transplantation A.U.Th., General Hospital of Thessaloniki Ippokratio.
Exclusion criteria
* Recent (\<12 months) Acute Myocardial Infraction * Recent (\<12 months) brain strokes * Uncontrolled and/or untreated arrythmia * Hepatic encephalopathy * Bed-bound patient * Liver Transplantation * Death
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from Baseline Liver Frailty Index value at 12 weeks | After 12-week exercise intervention | A frailty index for patients with cirrhosis, comprised of three performance-based metrics |
| Change from Baseline 6 Minute Walking Test value at 12 weeks | After 12-week exercise intervention | A walking test for patients to evaluate their functional capacity |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| VO2max | Before intervention initiation and after 12-week exercise intervention | Maximum oxygen consumption during incremental exercise |
Countries
Greece
Outcome results
None listed