Infertility, Male
Conditions
Brief summary
Donor sperm provides a viable option for patients with significant male factor infertility. However, since the source of sperm is not from the male partner, the psychological burden of these couples is more pronounced and complex than other patients.The purpose of this study is to investigate the stress faced by participants undergoing assisted reproduction with donor sperm and to further investigate its impact on pregnancy outcomes.
Detailed description
The number of infertility patients has increased significantly in recent years, and infertility caused by the male partner accounts for about 30%-50% of infertility factors. Donor sperm provides a viable option for patients with significant male factor infertility. However, since the source of sperm is not from the male partner, the psychological burden of these couples is more pronounced and complex than other patients. Many factors such as social, marital, and family problems may contribute to their depressed emotional state. And the impact of these negative emotions on pregnancy outcomes cannot be ignored. In this study, investigators intend to investigate the stress faced by participants undergoing assisted reproduction with donor sperm to provide a reliable basis for future psychological interventions and health education for this group of patients and improve the quality of life of infertility patients.
Interventions
OTHERExposure: donor sperm
One group use donor sperm through the process of assisted reproduction and the other uses husband's semen.
Sponsors
Women's Hospital School Of Medicine Zhejiang University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Female partners' \>18\< 40 years * Male partners' \>18\< 40 years * Patients undergoing assisted reproductive technology with donor sperm or husband's semen due to male factor
Exclusion criteria
* Female partners with polycystic ovary * Female partners with insufficiency or premature ovarian failure * Female partners with endometriosis * Female partners with abnormal profile of thyroid hormones * Chromosomal abnormalities of either spouse * Mental disorder of either spouse
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Implantation rate | 8 months | Implantation rate is defined as number of sacs per embryo transferred. |
| clinical pregnancy rate | 8 months | presence of at least one gestational sac on ultrasound of 6 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Total gonadotropin use | 8 months | Total gonadotropin use of each participant |
| Ovarian hyperstimulation syndrome (OHSS) rates | 8 months | OHSS rates in both study groups |
| fertilization rate | 8 months | No. of fertilized oocyte divided by No. of inseminated cumulus-oocyte complexes (COCs) |
| Metaphase II (MII) oocytes | 8 months | the number of mature oocytes |
| Number of oocytes retrieved | 8 months | — |
| cleavage rate | 8 months | No. of cleaved embryo divided by No. of fertilized oocyte |
Countries
China
Contacts
Primary ContactYimin Zhu, Dr.
Outcome results
None listed