ANCA Associated Vasculitis
Conditions
Keywords
peripheral neuropathy
Brief summary
1. Include qualified 50 ANCA-associated vasculitis(AAV) patients; and the first 27 patients will be divided into 3 groups with different diffused tension image (DTI) parameters and to choose the best strategy； 2. On baseline, 6 months after treatment and 24 months after treatment, the AAV patients will accomplish the Birming-ham vasculitis activity score(BVAS) besides DTI； 3. The new serum biomarkers of AAV associated peripheral neuropathy will be measured by ELISA； (4) Another cohort with 50 patients with AAV associated peripheral neuropathy who were evaluated by traditional methods (electromyogram) and compared to the patients cohort that evaluated using DTI by cost-benefit analysis
Interventions
OTHERdiffusion tensor imaging(DTI) evaluation
DTI is a new kind of MRI technique to evaluate peripheral neuropathy
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Inclusion criteria
* age between 18-80 years old； * must fulfill 2012 criteria of ANCA associated vasculitis * presented with peripheral neuropathy diagnosed by specialists
Exclusion criteria
* the ANCA associated vasculitis is already in the stable stage after treatments * any vital organ dysfunction * active infection or cancer * can not finish DTI scan
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To assess the optimal b-value (a key parameter) for DTI in AAV associated peripheral neuropathy | 2 years | b-value is a key technique parameter for DTI, which will decide the quality of DTI image |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the association between normative diffusion value of DTI (FA and ADC value) and disease activity activity score of AAV (BVAS). | 2 years | Birmingham Vasculitis Activity Score (BVAS) is a index of vasculitis disease activity, with the score range 0-63. Fractional anisotropy(FA) and apparent diffusion coefficient(ADC) are two parameters that can be read through DTI image . |
| the association between normative diffusion value of DTI (FA and ADC value) and serum biomarkers of AAV associated neuropathy | 2 years | sCD163, Nfl（neurofilament light polypeptide）and OPN（osteopontin）are new biomarkers of peripheral neuropathy |
Countries
China
Contacts
Primary Contactwenjia sun
Backup Contactting zhang
Outcome results
None listed