Secondary Hyperparathyroidism;Parathyroidectomy
Conditions
Keywords
Secondary Hyperparathyroidism;Parathyroidectomy;hemodialysis
Brief summary
Total parathyroidectomy with autotransplantation (TPTX+AT) and Total parathyr- oidectomy alone (TPTX) are the common surgical procedures.The purpose of the study was to compare the long-term benefits of surgery between the two groups.
Detailed description
The trial was performed as a nonconfirmatory randomized controlled pilot trial with 200 patients on long-term dialysis with otherwise uncontrollable SHPT to generate data on the rate of recurrent disease within a 5-year follow-up period after TPTX or TPTX+AT. Parathyroid hormone (PTH) and calcium levels, recurrent or persistent hyperparathyroidism, parathyroid reoperations, morbidity, and mortality were evaluated during a 5-year follow-up.
Interventions
PROCEDUREParathyroidectomy
Total Parathyroidectomy With Autotransplantation or Total Parathyroidectomy Alone
Sponsors
The Second Hospital of Nanjing Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
Severe renal secondary hyperparathyroidism
Exclusion criteria
Patients with diabetes a history of chronic inflammatory disease a history of malignant tumor a history of kidney transplantation a history of neck surgery a history of alcohol abuse a history of drug abuse inability to cooperate with the participants refusal to participate in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the rate of recurrent | 60 months | the rate of recurrent |
Countries
China
Contacts
Primary ContactMingxia XIONG, Ph.D
Outcome results
None listed