Gastrointestinal Dysfunction, Lidocaine, Opioid Consumption, Pain, Spinal Surgery
Conditions
Keywords
Lidocaine, Gastrointestinal Dysfunction, Spinal surgery, Opioid consumption
Brief summary
Spinal surgery often involves multiple segments. The trauma of surgery is large, the duration of postoperative pain is long, and the pain is severe. Therefore, the use of opioids in perioperative period is large. Although the application of \* large amounts of opioids can effectively inhibit pain, it will delay the recovery of urine retention, sedation, respiratory depression and gastrointestinal function. The delayed recovery of gastrointestinal function will increase the postoperative complications, and then increase the length of hospital stay and the cost of patients. Therefore, reducing the dosage of opioids to promote the recovery of gastrointestinal function has become the research direction. Intravenous lidocaine has been proved to be effective in reducing the dosage of opioids during the perioperative period of gastrointestinal surgery and promoting the recovery of postoperative gastrointestinal function. However, there are few studies on the application of lidocaine during the perioperative period of spinal surgery, especially the impact on postoperative gastrointestinal function. In this study, a multicenter, randomized, double-blind, controlled study was conducted to explore the effect of perioperative lidocaine on the recovery of gastrointestinal function after adult lumbar surgery. We hypothesized that lidocaine could shorten the recovery time of gastrointestinal function after lumbar surgery
Interventions
DRUGLidocain
Patients received 1.5mg/kg of intravenous lidocaine during induction of anesthesia and 1.5 mg/kg/h for anesthesia maintenance.
DRUGnormal saline
Patients received 0.075ml/kg of intravenous normal saline during induction of anesthesia and 0.075ml/kg/h for anesthesia maintenance.
Sponsors
Wangjing Hospital, China Academy of Chinese Medical Sciences
First Affiliated Hospital of Guangxi Medical University
Peking University People's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
60 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. age 60 to 80; 2. ASA physical status score of I, II or III; 3. Scheduled to undergo a posterior lumbar surgery; 4. Ideal body weight≤80 kg;
Exclusion criteria
1. Those who are refused to be included; 2. Those who are allergic to the drugs used in this study; 3. Emergency operation 4. Degree II or III atrioventricular block 5. heart failure 6. History of ALS, preexcitation or active dysrhythmia 7. Severe liver injury (bilirubin \> 1.46 mg/dl) 8. Severe renal injury (creatinine clearance \< 30 ml/min) or Renal failure 9. History of epilepsy 10. History of porphyria 11. Preoperative hypotension (SBP\< 90mmHg) 12. Drug contraindications of NSAIDs 13. Allergic to anaesthetic
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| First anal exhaust time | Day 0 | Time of first anal exhaust after operation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| First defecation time | Day 0 | Time of first defecation after operation |
| First diet time | Day 0 | Time of first feeding after operation |
| Time to get out of bed | Day 0 | Time to get out of bed after operation |
Countries
China
Contacts
Primary ContactJie Gu, attending
Outcome results
None listed