Coronary Artery Disease
Conditions
Brief summary
Older adults with coronary artery disease (CAD) have impaired vascular and inspiratory muscle function. The objective of this study is to examine the effect of beet juice supplementation on vascular and inspiratory muscle function in older adults with CAD.
Interventions
DIETARY_SUPPLEMENTNitrate rich beetroot juice
Participants will drink nitrate rich beetroot juice (2.4 floz ; Beet It Sport Nitrate 400 concentrated beetroot shot; James White Drink, ltd) twice daily for two weeks.
DIETARY_SUPPLEMENTNitrate depleted beetroot juice
Participants will drink nitrate depleted beetroot juice (2.4 floz ; Beet It placebo concentrated beetroot shot; James White Drink, ltd) twice daily for two weeks.
Sponsors
University of Florida
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
60 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Adults with coronary artery disease (CAD) based on an angiogram \>50% stenosis in any major epicardial vessel or history of myocardial infarction or history of coronary revascularization. * Considered to have stable CAD on optimal medical therapy * 60 to 85 years of age * Men and women (women must be postmenopausal either natural or surgical) * Able to give consent
Exclusion criteria
* Ejection fraction \<50%, unstable angina, recent myocardial infarction within 6 months * Coronary revascularization, including percutaneous coronary intervention and coronary artery bypass graft or thoracic surgery within 6 months. * Stroke, obstructive pulmonary disease, hepatitis B, C, HIV, seizures, or other relevant on-going or recurrent illness * Individuals that have participated in respiratory training within the last 12 months or cardiac rehabilitation within the last 6 months * Uncontrolled hypertension * Use of tobacco products including smoking traditional or e-cigarettes * Use of hormone replacement therapy in women or men (e.g., estrogen, progesterone or testosterone) * Regular aerobic exercise training * Unwilling to stop using mouthwash at least 1 week before the start of the study and during study participation * Unwilling to remain weight stable during study participation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in endothelial function | Baseline up to following 2 weeks of experimental condition | Endothelial function will be determined using brachial artery flow-mediated dilation via high resolution duplex ultrasonography. Reactive hyperemia will be produced by inflating a forearm cuff to \ 250 mmHg for 5 minutes followed by rapid deflation. |
| Change in inspiratory muscle function | Baseline up to following 2 weeks of experimental condition | Inspiratory muscle function including strength, power and endurance will be assessed using the POWERbreathe KH2 device |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in microvascular function | Baseline up to following 2 weeks of experimental condition | Microvascular function will be assessed using the forearm blood flow response to submaximal handgrip exercise. Brachial artery blood flow and diameter will be assessed using ultrasound. |
| Change in central arterial stiffness | Baseline up to following 2 weeks of experimental condition | The SphygmoCor XCEL device will be used to measure carotid to femoral pulse wave velocity. |
| Change in central arterial hemodynamics | Baseline up to following 2 weeks of experimental condition | The SphygmoCor XCEL device will be used to obtain central pulse wave analysis. |
| Change in functional capacity | Baseline up to following 2 weeks of experimental condition | Using the Duke Activity Status Index we will assess participants' ability to perform daily activities. |
Countries
United States
Contacts
Primary ContactDemetra Christou, PhD
Backup ContactStephanie Lapierre, MS
Outcome results
None listed