Postoperative Pain
Conditions
Keywords
Erector spinae block., dexmedetomidine., Postoperative analgesia
Brief summary
60 female patients scheduled for breast cancer surgeries, allocated in 3 groups for erector spinae block with bupivacaine and erector spinae block with dexmedetomidine added to bupivacaine and control group. During anesthesia: total intraoperative fentanyl required will be recorded. After surgery the first time of request for analgesic will be recorded. after request of analgesia all patients will be connected to PCA device containing morphine solution, the amount of morphine consumed during the first 24 hours will be recorded.
Detailed description
60 female patients scheduled for breast cancer surgeries, allocated in 3 groups for erector spinae block with bupivacaine and erector spinae block with dexmedetomidine added to bupivacaine and control group. During anesthesia: total intraoperative fentanyl required will be recorded. After surgery the first time of request for analgesic will be recorded. after request of analgesia all patients will be connected to PCA device containing morphine solution, the amount of morphine consumed during the first 24 hours will be recorded. Other secondary outcomes are numerical rating scales and incidence of opioid side effects.
Interventions
Patients will receive a sonar-guided erector spinae plane block with 20 ml of bupivacaine 0.5%
PROCEDUREerector spinae block with bupivacaine + dexmedetomidine
Patients will receive a sonar-guided erector spinae plane block with 19 ml of bupivacaine 0.5%+ 1 ml dexmedetomidine
Sponsors
Mohamed Elsayed Hassan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Provision of signed and dated informed consent form * Stated willingness to comply with all study procedures and availability for the duration of the study * Female, aged (18-70) years * Belongs to American Society of Anaesthesiologists physical status class II. * Scheduled for breast cancer surgeries.
Exclusion criteria
* Patient refusal. * Local infection at the site of the block. * Cardiac dysfunction (ejection fraction \<45%). * Preexisting neurological or psychiatric disease, communication difficulties, inability to use the patient-controlled analgesia (PCA) device. * Allergy to one of the study drugs. * Pregnancy. * Coagulopathy (PC \<60% and platelet count\<100.000).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time to first request of analgesia | The first postoperative day | Time from recovery of anesthesia till first request for analgesia to relive pain. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Total morphine consumption in first postoperative 24 hours | First 24 postoperative hours | The amount of morphine required to relieve pain will be recorded |
| Intraoperative fentanyl requirement | During anesthesia | The amount of fentanyl required during anesthesia will be recorded |
| Numerical rating scale | The first 24 postoperative hours | Numerical rating scale (from 0 to 10, where 0 represents no pain and 10 represents the worst imaginable pain) will be recorded in different time intervals during the first 24 hours after surgery |
Countries
Egypt
Outcome results
None listed