Contrast Sensitivity, Keratomileusis, Laser In Situ
Conditions
Brief summary
To compare the efficacy to different profiles, direct head-to-head studies had been conducted. In one previous review study revealed that TG LASIK provided patient with better uncorrected visual acuity (UCVA) than WFO LASIK and WFG LASIK. In recent previous contralateral eye studies also showed that TG LASIK induced less postoperative higher-order aberration than WFO LASIK. However, these studies included only low-to-moderate myopia patients, for patients with high myopia (spherical equivalent \> 6D), the effect of TG LASIK comparing with WFO LASIK had not been reported before. The aim of our study is to analyze and compare the visual performance of TG LASIK and WFO LASIK in high myopia and low-to-moderate myopia patients, , particularly UCVA, corrected distance visual acuity (CDVA), contrast sensitivity (CS), and wavefront aberration.
Interventions
DEVICETopoguided LASIK
Topoguided ablation profile on dominant eye
Wavefront optimized ablation profile on non-dominant eye
Sponsors
Taipei Nobel Eye Clinic
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* age between 20 and 50 years old * CDVA of both eyes could reach 0.1 logarithm of the minimum angle of resolution (logMAR) * stable refractive errors of myopia and astigmatism
Exclusion criteria
* cataract * corneal opacities or irregularities * dry eye (Schirmer's test I ≤ 5mm) * amblyopia * coexisting ocular pathologies * glaucoma * non-dilating pupil * history of intraocular surgery, laser therapy, or retinopathy * optic nerve or macular diseases * estimated postoperative cornea residual stromal thickness less than 250 μm * pregnancy or under lactation * uncontrolled diabetic mellitus or systemic immune disease * refusal or unable to maintain follow-up
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Visual acuity | 3 months after surgery | uncorrected visual acuity and corrected distance visual acuity |
| Corneal wavefront analysis | 3-months postoperative visit | horizontal coma aberration (Z 3,1), spherical aberration (Z 4,0), and trefoil aberration |
| Contrast sensitivity | 3-months postoperative visit | 4 spatial frequencies: 3, 6, 12, and 18 cycles per degree (cpd). |
| Quality of vision questionnaire | 3-months postoperative visit | A 11-item questionnaire, item scores range from 0 to 10 and higher item scores in questionnaire indicated more difficulty in achieving specific visual tasks |
Countries
Taiwan
Outcome results
None listed