Obstructive Lung Disease
Conditions
Keywords
obstructive lung disease, total lung capacity, the single-breath helium dilution, Whole-body plethysmography, correction equation
Brief summary
Whole-body plethysmography (WBP) is the gold standard for measuring lung volume, but its clinical application is limited because it requires expensive equipment and is complicated to use. Studies have shown that the single-breath helium dilution (SBHD) method, which is commonly used in clinical practice, significantly underestimates lung volume in patients with obstructive lung disease (OLD). Therefore, by comparing the differences in lung volume measured by the SBHD method and WBP in patients with different severities of obstructive lung disease, we aim to establish a correction equation for the SBHD method to determine the total lung volume in obstructive lung disease patients.
Interventions
DIAGNOSTIC_TESTthe single-breath helium dilution method and Whole-body plethysmography
The patients with obstructive lung disease simultaneously subjected to the single-breath helium dilution method and Whole-body plethysmography tests.
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
(1) age 18-80 years and (2) in line with the ATS/ERS definition of obstructive lung disease.
Exclusion criteria
(1) contraindications for spirometry, pulmonary diffusion function test, and WBP and (2) history of lung surgery and recent history of chest trauma.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Establishment of the TLC-SBHD correction equation | 2 year | TLC-adjusted SBHD (L) = -0.669 + 0.756 × TLC-SBHD (L) - 0.047 × FEV1/FVC + 0.039 × height (cm) - 0.009 × weight (kg) (r2 = 0.753 and adjusted r2 = 0.751) |
Countries
China
Outcome results
None listed