Beta Thalassemia
Conditions
Brief summary
The production of Hb F after birth is an important factor in modifying the clinical severity of beta thalassemia because an increased gamma-globin level will bind the additional a-globin and form Hb F. The objective of this project is to evaluate the association of Hb F level with phenotypic diversity of patients with beta thalassemia.
Interventions
DIAGNOSTIC_TESTHematological Phenotype Analysis
Hematological parameters were determined with an automated hematology analyzer (Sysmex, Japan), and hemoglobin analysis was performed with either high-performance liquid chromatography (Bio- Rad, USA) or capillary electrophoresis (Sebia, France and Helena, USA).
Sponsors
ZhuHai Hospital
Shenzhen Children's Hospital
Shenzhen Second People's Hospital
Jiangmen Maternity and Child Health Care Hospital
Yongzhou Maternity and Child Health Hospital
Nanfang Hospital, Southern Medical University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Diagnosed with beta-thalassemia
Exclusion criteria
* Iron Deficiency Anemia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hb F level and severity of anemia | 3 years | Observational study that analyzed association of Hb F level and anemia severity in patients |
Countries
China
Contacts
Primary ContactXiangmin Xu, Prof. Dr.
Outcome results
None listed