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Effect of Nitrate on Red Blood Cell Function in Type 2 Diabetes

The Effect of Dietary Nitrate Supplementation on Red Blood Cell Function in Patients with Type 2 Diabetes

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04917471
Enrollment
20
Registered
2021-06-08
Start date
2021-06-01
Completion date
2025-12-31
Last updated
2024-10-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 Diabetes

Brief summary

To investigate the effect of nitrate supplementation on red blood cell function in patients with type 2 diabetes.

Interventions

DIETARY_SUPPLEMENTBeet root juice

70 ml bid

DIETARY_SUPPLEMENTPlacebo juice

70 ml bid

Sponsors

Karolinska Institutet
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Type 2 diabetes

Exclusion criteria

Acute coronary syndrome Vegetarian diet Impaired renal function Absolute indication for proton pump inhibitor Ongoing treatment with organic nitrate Heart failure (ejection fraction \<35%) Any condition that interferes with the possibility to fulfill the study protocol

Design outcomes

Primary

MeasureTime frameDescription
Percentage recovery of left ventricular function1 weekRed blood cells are administered to an isolated rodent heart subjected to 25 min global ischemia and 60 min reperfusion. The percentage recovery during reperfusion is determined.

Countries

Sweden

Contacts

Primary ContactJohn Pernow
john.pernow@ki.se+46704848361

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026