A Prediction Model of 28-day Mortality in Septic Shock

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04915625

Enrollment

530

Registered

2021-06-07

Start date

2020-12-01

Completion date

2022-12-31

Last updated

2021-06-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Septic Shock

Keywords

mortality, Predictive model

Brief summary

This clinical study adopts the design of cohort research, selects the sepsis shock patients admitted to our hospital ICU as the research object, takes the 28-day mortality rate as the outcome index, collects the baseline data of the patient, the severity of the disease, vital signs, the main infection site, the laboratory-related index, the treatment method and other data, screens out the risk factors affecting the sepsis shock 28-day mortality rate and constructs the prediction model accordingly, analyzes the prediction model with the subject's working characteristic curve (ROC). The recognition ability of the model is calculated by the area under the ROC curve (AUC) and the ability of the model to predict 28-day mortality with SOFA and APACHE II.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Age ≥ 18 years of age, gender-neutral; 2. Diagnosed with sepsis shock; 3. ICU survives longer than 48 h; 4. The preservation of clinical data is complete;

Exclusion criteria

\- Diagnosed with sepsis shock within 6 hours of emergency treatment; Combined with people with autoimmune diseases; 3. Organ transplantation or immunosuppressive treatment; 4. Severe heart, liver and kidney insufficiency; 5. Late stage of malignant tumor; 6. Maternity; 7. Referral or referral to another hospital;

Design outcomes

Primary

Measure	Time frame	Description
All causes of 28 days mortality	28 days	The all-cause mortality rate is measured from the time the ICU is admitted to the hospital and 28 days after admission (regardless of ICU, hospitalization or out-of-hospital mortality).

Secondary

Measure	Time frame	Description
ICU hospitalization time	2 years	hospitalization time
hospitalization mortality	2 years	—

Countries

China

Contacts

Primary ContactMAN HUANG, MD PHD

huangman@zju.edu.cn+86 13906518699

Outcome results