Hyperglycemia, Postprandial
Conditions
Brief summary
This study aims to evaluate and select the best combination of polyphenol and white kidney bean ingredients in the acute glycemic modulation after a complete meal by measuring blood glucose and insulin.
Interventions
DIETARY_SUPPLEMENTVerum T1
Verum T1 is a placebo: microcristalline cellulose. Daily dosage is 1000 mg in 3 capsules.
DIETARY_SUPPLEMENTVerum T2
Verum T2 is a 11500AAIU/g white kidney bean extract. Daily dosage is 1000 mg in 3 capsules.
DIETARY_SUPPLEMENTVerum T3
Verum T3 is a 11500AAIU/g white kidney bean extract. Daily dosage is 565 mg in 3 capsules
DIETARY_SUPPLEMENTVerum T4
Verum T4 is a 17500AAIU/g white kidney bean extract. Daily dosage is 1000 mg in 3 capsules
DIETARY_SUPPLEMENTVerum T5
Verum T5 is a 17500AAIU/g white kidney bean extract. Daily dosage is 371 mg in 3 capsules
DIETARY_SUPPLEMENTVerum T6
Verum T6 is a 34200AAIU/g white kidney bean extract. Daily dosage is 1000 mg in 3 capsules
DIETARY_SUPPLEMENTVerum T7
Verum T4 is a 34200AAIU/g white kidney bean extract. Daily dosage is 512 mg in 3 capsules
DIETARY_SUPPLEMENTVerum T8
Verum T8 is a 34200AAIU/g white kidney bean extract. Daily dosage is 190 mg in 3 capsules.
DIETARY_SUPPLEMENTVerum T9
Verum T9 is a polyphenol mix extract ( olive leaf, and blackcurrant extract). Daily dosage is 1000 mg in 3 capsules
DIETARY_SUPPLEMENTVerum T10
Verum T10 is a polyphenol mix extract ( olive leaf, and blackcurrant extract). Daily dosage is 500 mg in 3 capsules
DIETARY_SUPPLEMENTVerum T11
Verum T11 is a polyphenol mix extract ( olive leaf, pomelo, pomegranate, and blackcurrant extract). Daily dosage is 900 mg in 3 capsules
DIETARY_SUPPLEMENTVerum T12
Verum T12 is a polyphenol mix extract ( olive leaf, pomelo, pomegranate, and blackcurrant extract). Daily dosage is 600 mg in 3 capsules
DIETARY_SUPPLEMENTVerum T13
Verum T13 is a polyphenol mix extract ( olive leaf, pomelo, pomegranate, and/or blackcurrant extract) with white kidney bean extract. Daily dosage is 1000 mg in 3 capsules.
DIETARY_SUPPLEMENTVerum T14
Verum T14 is a polyphenol mix extract ( olive leaf, pomelo, pomegranate, and/or blackcurrant extract) with white kidney bean extract. Daily dosage is 900 mg in 3 capsules.
DIETARY_SUPPLEMENTVerum T15
Verum T15 is a polyphenol mix extract ( olive leaf, pomelo, pomegranate, and/or blackcurrant extract) with white kidney bean extract, Zinc, and, black currant leaf extracts. Daily dosage is 1000 mg in 3 capsules.
DIETARY_SUPPLEMENTVerum T16
Verum T16 is a polyphenol mix extract ( olive leaf, pomelo, pomegranate, and/or blackcurrant extract) with white kidney bean extract, and Zinc. Daily dosage is 1000 mg in 3 capsules.
DIETARY_SUPPLEMENTVerum T17
Verum T17 is a placebo: microcristalline cellulose. Daily dosage is 1000 mg in 3 capsules.
Sponsors
Fytexia
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Glycemia: 100-125mg/dL * Both sexes * Overweight BMI range (27-32) * Age: 20-50 years old
Exclusion criteria
* Metabolic/Chronical disease * Menopausal women * Being pregnant, breastfeeding or wanting to have a baby * Former obese with a history of yoyo effect * Have been involved in a weight loss program in the past 12 months or subjected to weight reduction surgery * Having started or quit smoking, having a high alcohol consumption * Have in the past been in a long-term antibiotherapy (1 month or more) and/or a regular antibiotherapy in the past 12 months * Allergy to olive, artichoke, black currant, grapefruit, grape, white kidney bean, olive, pomegranate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute change in glycemia in response to a meal, by measuring glucose concentration in the blood at different time points | 8 hours |
Secondary
| Measure | Time frame |
|---|---|
| Lipid profile evolution after a meal | 8 hours |
| Oxxidative stress variation after a meal, measured by oxidized/reduced glutathione (GSH/GSSG) | 8 hours |
| Acute change in insulinemia in response to a meal, by measuring insulin concentration in the blood at different time points | 8 hours |
Countries
Spain
Outcome results
None listed