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Artificial Intelligence for Sepsis Prediction in ICU

Application of Artificial Intelligence Sepsis Prediction Model to Assist ICU Clinical Decision

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04913181
Acronym
AICUSepsis
Enrollment
2000
Registered
2021-06-04
Start date
2021-06-01
Completion date
2023-06-01
Last updated
2021-06-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Artificial Intelligence, Intensive Care Unit Psychosis, Septic Shock

Brief summary

The development of sepsis prediction model in line with Chinese population, and extended to clinical, assist clinicians for early identification, early intervention, has a good application prospect. This study is a prospective observational study, mainly to evaluate the accuracy of the previously established sepsis prediction model. The occurrence of sepsis was determined by doctors' daily clinical judgment, and the results of the sepsis prediction model were matched and corrected to improve the clinical accuracy and applicability of the sepsis prediction model.

Detailed description

The sepsis prediction model adopted in this study has been completed in the preliminary preparation, which was constructed on 7,000 patients since the establishment of comprehensive ICU, and the sepsis 3.0 diagnostic standard was adopted.The sepsis prediction model was built using Python platform and XGBoost algorithm, which was used to predict the incidence of sepsis in ICU patients within 24 hours. The overall accuracy was 82%, and the area under the Auroc curve was 0.854. Patients who met the inclusion and exclusion criteria were given a daily prediction of sepsis model, and a quantitative checklist was formed based on the test results.There are two kinds of forecast outcomes: low risk and high risk.Quantitative checklists are available to attending physicians to improve diagnostic efficiency.The results were kept confidential to the clinician. All patients were diagnosed with sepsis by two senior attending physicians at a fixed time. The diagnosis consisted of two types: yes and no.If two attending physicians have different opinions, the third attending physician will be included for correction diagnosis, and the presence of sepsis will be determined in a 2:1 manner.The attending physicians are independent of each other. When the diagnosis results of the attending physician are input into the system, the prediction results of yesterday's sepsis prediction model are compared and calculated to determine the accuracy of the prediction model

Interventions

DIAGNOSTIC_TESTArtificial intelligence sepsis prediction model

The main purpose of this paper is to evaluate the accuracy of the sepsis prediction model established in the early stage. The occurrence of sepsis is determined by the daily clinical judgment of doctors, and the results of sepsis prediction model are matched and corrected.

Sponsors

Second Affiliated Hospital, School of Medicine, Zhejiang University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
16 Years to 100 Years
Healthy volunteers
No

Inclusion criteria

All patients with acute critical illness who are eligible for admission to ICU during the study period

Exclusion criteria

1. Patients under the age of 16; 2. Pregnant and parturient women; 3. Patients who planned to be admitted to the department for surgery and transferred the next day after evaluation; 4. Patients admitted to the department and diagnosed with sepsis; 5. Patients with ICU stay less than 24 hours;

Design outcomes

Primary

MeasureTime frameDescription
Accuracy of model diagnosis2 yearsEvaluation of the accuracy of prediction model in clinical application

Contacts

Primary Contact琦强 梁
deter_leung@sina.com13685753994

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026