Circulating Tumor Cell, Colorectal Cancer
Conditions
Brief summary
Detecting circulating tumor cells from I-IV stage colorectal cancer patients pre-and post-operatively. Analyzing the morphology and biomarkers of CTCs and builting prognosis predicting model based on the morphology and biomarkers of CTCs. Verifying the prognosis model by the survival data.
Interventions
DIAGNOSTIC_TESTCirculating tumor cell
detecting circulating tumor cell pre- and post operatively
Sponsors
Fudan University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-80 years; Histologically proven colorectal carcinoma (TNM stage I-IV) R0 resection is possible according to preoperative evaluation Written informed consent for participation in the trial.
Exclusion criteria
* Primary tumor or metastases not able to be removed radically Receiving any preoperative treatment (Including chemotherapy, radiotherapy and target therapy) Have other malignant tumors meanwhile Other previous malignancy within 5 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sensitivity | 1 year | The sensitivity of the predictive based on the number and type of circulating tumor cell |
| Specificity | 1 year | The specificity of predictive model based on the number and type of circulating tumor cell |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| AUC | 1 year | Area under curve of the predictive model |
Contacts
Primary ContactJianmin Xu
Outcome results
None listed