Debility
Conditions
Keywords
intestinal flora
Brief summary
This study intends to recruit aging population (over 65 years old). The investigators use 16 SrDNA sequencing technology, genome sequencing technology, metabonomics, random forest forecast model, analysing and selecting specific age-related intestinal flora. The investigators select probiotics slowing down senility. Then the investigators use the probiotics to intervene in the aging population. Finally the investigators observe whether the probiotics can delay aging.
Detailed description
This project plans to recruit the aging population (aged over 65 years old) and comprehensively analyze the public database and self-sequencing clinical big data by using 16 srDNA sequencing technology, metagenomic sequencing technology, metabonomics methods and Random Forest (R) prediction model to judge the key bacterial communities and related functional pathways related to aging.Based on the analysis results, the probiotics with the potential to alleviate aging were selected for intervention evaluation of aging population. This topic aims to explore the change process of intestinal flora structure and composition related to aging process.Identify the key intestinal bacteria genera/species/strains associated with aging, and target the pathway and metabolic characteristic spectrum of the key bacterial communities associated with aging;And select and breed specific intestinal bacterial strains related to aging.The aim is to reduce the age-related metabolic abnormalities and chronic inflammation, reduce medical treatment, rationally allocate medical resources, reduce medical costs and improve the quality of life.
Interventions
DIETARY_SUPPLEMENTBifidobacterium longum
types of intestinal flora
DIETARY_SUPPLEMENTA placebo made of starch
placebo
Sponsors
Jiangnan University
Wuxi People's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Masking description
Participant ,care provider,investigator and outcomes Assessor are all blind.
Intervention model description
One group served as a control group, while the other three groups are treated with different strains of bifidobacterium longum
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Over 65 years old 2. Frail scale score above 3 points
Exclusion criteria
1. Severe impairment of liver and kidney function 2. The tumor is advanced and life expectancy is less than 2 years 3. Severe cognitive impairment and inability to cooperate 4. Unable to give informed consent 5. Have participated in other study before
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Points of probiotics intervention in aging population | one year | The score of Frail scale 0 points is defined as normal.And 1 to 3 points is defined as the early age of debility.Three points or more is defined as debility.The score is lower than before, meaning probiotic intervention can alleviate debility. |
Contacts
Primary ContactKan Hong, doctor
Outcome results
None listed