Appetitive Behavior, PreDiabetes
Conditions
Keywords
Resistance Exercise, Pre Diabetes, Appetite
Brief summary
The purpose of the study is to learn about how type of exercise influences measures of appetite regulation.
Detailed description
The primary objective of this study is to understand the relationship between exercise modality and appetite regulation in a population with pre-diabetes. The study includes a screening visit to ensure eligibility of participants, baseline assessments, a resistance exercise intervention, and post intervention measurements. The variables of interest include, but are not limited to, hormonal responses to exercise training pertaining to appetite, food cravings, appetite ratings. activity levels, body composition, and ten repetition-max strength. The aim of this study is to better understand the mechanisms involved in the correlation or causation of any improvements in fitness and appetite regulation in a cohort with pre-diabetes.
Interventions
BEHAVIORALResistance Exercise
Increasing strength and fitness and thereby influencing hormones and perceptions involved in appetite regulation.
Sponsors
University of Utah
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Participants are randomly assigned to one of the two intervention groups.
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18-50 years of age * BMI between 27-40 kg/m² * Hemoglobin A1c level between 5.7% and 6.4% * Physical Activity (less than 150 min/week moderate-intensity Physical Activity, no more than 1 session/week of resistance exercise)
Exclusion criteria
* Unstable Cardiovascular Disease * Uncontrolled hypertension * Severe hypertriglyceridemia * History of or active liver disease * Uncontrolled thyroid disease * Active cancer diagnosis * Smoking * Engaged in exercise or diet program * History of bariatric surgery * GI malabsorptive disorders * Significant diet intolerances * History of major psychiatric disorder * presence of alcohol or substance abuse; * medications affecting weight, * EI or EE in past 6 months; * women currently pregnant, lactating, less than 6 months post-partum, or postmenopausal.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Appetite Rating | Baseline: Pre-Meal , 30 minutes, 60 minutes, 90 minutes, and 120 minutes post meal / Post-intervention(Week 4) :Pre-Meal, 30 minutes, 60 minutes, 90 minutes ,and 120 minutes post meal | Hunger/Satiety before/after consumption of a meal |
| Changes in Hormonal Response to Feeding | Baseline: Pre-Meal , 30 minutes, 60 minutes, 90 minutes, and 120 minutes post meal / Post-intervention(Week 4) :Pre-Meal, 30 minutes, 60 minutes, 90 minutes ,and 120 minutes post meal | Assessment of Ghrelin levels analyzed in blood samples before/after feeding. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Physical Activity Levels | Baseline and Post-intervention(Week 4) | Measured via ActivPal Monitor |
| Changes in Food-Related Behaviors | Baseline and Post-intervention(Week 4) | Evaluated via the Food Craving Inventory |
| Changes in Body Composition | Baseline and Post-intervention(Week 4) | Measured via BodPod |
| Changes in Ad libitum Energy Intake - Free Living | Baseline and Post-intervention(Week 4) | 3 days of free-living ad libitum energy intake (via self-report) |
| Change in Ad libitum Energy Intake - In lab | Baseline and Post-intervention(Week 4) | In lab ad libitum buffet lunch (via weigh and measure methodology) |
| Changes in Maximal Strength | Baseline and Post-intervention(Week 4) | Measurement via 10 repetition-max testing. |
Countries
United States
Outcome results
None listed