Acute Myeloid Leukemia, Bloodstream Infection, Febrile Neutropenia
Conditions
Keywords
antibiotic short course, appropriate use of antibiotics
Brief summary
There is no specific recommendation about antimicrobial treatment length for documented infections in chemotherapy induced febrile neutropenia. The aim of this study was to compare long versus short antibiotic course for bloodstream infection treatment in acute myeloid leukemia patients during febrile neutropenia. This monocentric retrospective comparative study included all consecutive bloodstream infection episodes among acute myeloid leukemia patients with febrile neutropenia for 3 years (2017-2019). Episodes were classified regarding the length of antibiotic treatment, considered as short course if the treatment lasted ≤7 days, except for nonfermenting bacteria and Staphylococcus aureus or lugdunensis for which the threshold was ≤10 days and ≤14 days, respectively. The primary outcome was the number of bloodstream infection relapses in both groups within 30 days of antibiotic discontinuation.
Interventions
DRUGAntibiotic
Antibiotic duration of treatment defined if the patient belonged to long course or short course group.
Sponsors
Poitiers University Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Acute myeloid leukemia * chemo-induced febrile neutropenia * Bloodstream infection
Exclusion criteria
* lack of data * endovascular infections * surgical treatment required * central nervous system infections * antibiotic treatment \< 4 days * death before the end of antibiotic treatment * unappropriated antibiotic treatment at 48h * relapses of bloodstream infection episodes already included * hematopoietic stem cell transplant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bloodstream infection relapses | within 30 days of antibiotic discontinuation | The primary outcome was to compare the number of bloodstream infection relapses in both groups within 30 days of antibiotic discontinuation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mortality | within 30 days of antibiotic discontinuation | Comparison of mortality rate within 30 days of antibiotic discontinuation |
| Epidemiology of bacteria | at baseline | Distribution of bacteria responsible for bloodstream infection |
| Risk factors for relapses | within 30 days of antibiotic discontinuation | Analyse of risk factors for bloodstream infection relapses |
Countries
France
Outcome results
None listed