Fat-lowering
Conditions
Brief summary
Overweight and obesity can lead to the occurrence of many chronic diseases. In addition to the body mass value (BMI), the excess body fat can also be used as criteria for assessing obesity. Citrus peels are rich in many substances including limonene, Nobiletin, 3-methoxynobiletin, and flavonoids. They could be used for lowering blood pressure and reducing blood pressure, anti-anxiety and sleep aid and etc. Fermentation technology is used to ferment the peel to increase the content of neutral components in citrus peel. Therefore, I want to evaluate whether the fermented orange peel enzyme has the effect of reducing fat.
Interventions
To evaluate whether the fermented orange peel enzyme has the effect of reducing body fat.
DRUGPlacebo
Placebo without orange peel fermentation
Sponsors
National Taiwan University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. Adults between the ages of 20 and 65 who are willing to sign the consent form of the subject. 2. For those with BMI ≥ 24 or fatty liver, men's body fat ≥ 25%, women's body fat ≥ 30% 3. Those who are not pregnant and are willing to cooperate with contraception during the trial period. 4. Those who have no history of cardiovascular disease, organ transplantation, epilepsy or convulsions, liver and kidney disease, malignant tumors, endocrine disease, mental disease, alcohol or drug abuse, and other major organic diseases (according to medical history).
Exclusion criteria
1. Pregnant women, people with a history of cardiovascular disease, organ transplantation, epilepsy or convulsions, liver and kidney disease, malignant tumors, endocrine diseases, mental illness, alcohol or drug abuse, and other major organic diseases (according to medical history). 2. Those who had undergone major surgery or bariatric surgery (according to medical history). 3. Currently or within 3 months before participating in the screening, those subjects used drugs that can affect body fat or increase weight significantly, such as systemic corticosteroids, tricyclic antidepressants, atypical psychiatric drugs, and mood stability Drugs (according to medical history) will be excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To evaluate whether the fermented orange peel enzyme has the effect of reducing fat. | 8 weeks | Obesity related markers |
Contacts
Primary ContactJyh-Ming Liou, MD
Outcome results
None listed