Aortic Valve Disease
Conditions
Keywords
Enterococci, Infective endocarditis, Antibiotic prophylaxis, TAVI
Brief summary
The general rules of antibiotic prophylaxis in surgery or interventional medicine include the choice of an antibiotic active on the bacteria most frequently encountered in surgical site infections. This antibiotic must cover, the bacteria present on the skin and recognized as responsible for surgical site infections. The aim of this study is to identify bacteria found in skin flora in the inguinal region of patients undergoing Transcatheter Aortic Valve Implantation (TAVI). Flora found will allow to evaluate the impact of skin preparation and antibiotic prophylaxis protocols as they are currently practiced.
Interventions
None listed
Sponsors
Clinique Pasteur
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient scheduled for aortic valve replacement by TAVI procedure with trans femoral approach * Patient with pre-TAVI assessment performed at Clinique Pasteur * Patient affiliated or beneficiary of a social security scheme * Patient accepting to participate and having given his no objection
Exclusion criteria
* TAVI procedure by non-trans femoral approach * Protected patients: Adults under guardianship or other legal protection; Pregnant or breastfeeding woman; Hospitalized without consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Enterococci prevalence | At Day 0 at TAVI intervention time (preoperative) | Proportion of patients with Enterococcus feacalis and other Enterococci in inguinal flora before TAVI |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Skin flora of the groin | At Day 0 at TAVI intervention time (preoperative) before skin disinfection | Bacteria profile of inguinal skin |
| Infectious events | From day of TAVI to 1 year after intervention | Occurrence of infective endocarditis or other infectious adverse events |
Countries
France
Contacts
STUDY_CHAIREric Bonnet, MD
Clinique Pasteur
STUDY_CHAIRNicolas Combes, MD
Clinique Pasteur
STUDY_CHAIRBenoit Fontenel, MD
Clinique Pasteur
Outcome results
None listed