Modified Radical Mastectomy, Pectoral Nerve (PECS) Block, Serratus Anterior Plane Block, Transeversus Thoracic Plane Blocks, Ultrasound-Guided
Conditions
Brief summary
The aim of this study is to evaluate the analgesic efficacy of combined ultrasound (US)-guided pectoral nerve (PECS) block II and transversus thoracic plane (TTP) block versus US-guided serratus anterior plane (SAP) block in female patients undergoing modified radical mastectomy.
Interventions
PROCEDUREPectoral nerve (PECS) block -transversus thoracic plane (TTP) block
Patients will receive unilateral US-guided PECS II block and TTP block on the side of the operation after induction of general anesthesia.
PROCEDURESerratus anterior plane (SAP) block
Patients will receive US-guided SAP block after induction of general anesthesia.
Sponsors
Tanta University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
21 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Female patients * Aged 21-60 years * ASA physical status I, II * Scheduled for unilateral modified radical mastectomy
Exclusion criteria
1. Patient refusal. 2. Known hypersensitivity to local anesthetics. 3. Body mass index \> 35 kg /m2. 4. Uncooperative or psychiatric patients. 5. Infection at the injection site. 6. Coagulation disorder.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The total amount rescue analgesic consumption (morphine) in the first 24 hours postoperatively. | First 24 hours postoperatively. | Rescue analgesia in the form of morphine (3mg IV) will be given if the VAS is ≥ 40, repeated with lock out interval of 5 min guided with the occurrence of complications till the VAS is decreased to less than 40. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The degree of postoperative pain | First 24 hours postoperatively. | Postoperative pain will be assessed by Visual Analog scale (VAS) on admission to Post-Anesthesia Care unit (PACU) and at 30 minutes and then 1,2,4,6,12,18 and 24 hours postoperative. VAS (0-100; where 0 represents no pain and 100 represents the worst pain). |
| Time to first rescue analgesia request. | First 24 hours postoperatively. | Rescue analgesia in the form of morphine (3mg IV) will be given if the VAS is ≥ 40, repeated with lock out interval of 5 min guided with the occurrence of complications till the VAS is decreased to less than 40. |
| Intraoperative fentanyl consumption. | Intraoperative | Additional boluses of fentanyl 0.5 µg /kg will be administered in case of inadequate analgesia that defined as increase of heart rate (HR) and /or mean arterial blood pressure (MAP) more than 20 % from baseline |
Countries
Egypt
Outcome results
None listed