MRI
Conditions
Brief summary
Patients who have agreed to participate in the study will complete the MRI protocol as part of routine care, to which a maximum of four additional 25-minute sequences will be added. MRI of routine care includes at least the following sequences: * 3D T1 TFE (2 minutes) * T2 TSE (2 minutes) * 3D FLAIR (3 minutes) The sequences added by the research lasting 25 minutes are: * SWI QSM 1.0iso 8 echoes (10 minutes) * SWI QSM 1.0iso 8 echoes CS 6 (7 minutes) * SWI QSM 1.0iso 8 echoes CS 9 (5 minutes) * SWI QSM 1.0iso 8 echoes CS 12 (3 minutes)
Detailed description
Patients who have agreed to participate in the study will complete the MRI protocol as part of routine care, to which a maximum of four additional 25-minute sequences will be added. MRI of routine care includes at least the following sequences: * 3D T1 TFE (2 minutes) * T2 TSE (2 minutes) * 3D FLAIR (3 minutes) The sequences added by the research lasting 25 minutes are: * SWI QSM 1.0iso 8 echoes (10 minutes) * SWI QSM 1.0iso 8 echoes CS 6 (7 minutes) * SWI QSM 1.0iso 8 echoes CS 9 (5 minutes) * SWI QSM 1.0iso 8 echoes CS 12 (3 minutes)
Interventions
DEVICEMRI
MRI of routine care includes at least the following sequences: * 3D T1 TFE (2 minutes) * T2 TSE (2 minutes) * 3D FLAIR (3 minutes) The sequences added by the research lasting 25 minutes are: * SWI QSM 1.0iso 8 echoes (10 minutes) * SWI QSM 1.0iso 8 echoes CS 6 (7 minutes) * SWI QSM 1.0iso 8 echoes CS 9 (5 minutes) * SWI QSM 1.0iso 8 echoes CS 12 (3 minutes)
Sponsors
Fondation Ophtalmologique Adolphe de Rothschild
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
For patients with MS: * Patient over 18 years old * Presenting MS defined according to McDonald's revised criteria for spatial and temporal clinical or radiological dissemination \[16\], * Should benefit as part of the care of an MRI examination with or without injection of gadolinium * Express consent to participate in the study * Affiliate or beneficiary of a social security scheme For patients with an indication to undergo a brain MRI and at low risk of inflammatory CNS disease: * Patient over 18 years old * Should benefit as part of the care of an MRI examination with or without injection of gadolinium * Express consent to participate in the study * Affiliate or beneficiary of a social security scheme
Exclusion criteria
* For patients with MS: * Patient benefiting from a legal protection measure * Pregnant or breastfeeding woman For patients with an indication to undergo a brain MRI and at low risk of inflammatory CNS disease: * Patient benefiting from a legal protection measure * Pregnant or breastfeeding woman * Patient with inflammatory and / or demyelinating pathology of the CNS Secondary
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| concordance of QSM signal with and without compressed-sensing in white matter | 1 DAY | concordance of QSM signal with and without compressed-sensing in white matter |
Countries
France
Outcome results
None listed