Gynecologic Disease
Conditions
Brief summary
The aim of this study is to investigate the effect of opioid-free anesthesia using dexmedetomidine and lidocaine instead of remifentanil infusion, on the acute postoperative pain after the gynecological laparoscopy
Detailed description
This study is performed to investigate the effect of dexmedetomidine and lidocaine the postopeative pain, shivering, nausea and vomiting after the gynecological laparoscopy.
Interventions
DRUGDexmedetomidine Hydrochloride
dexmedetomidine iv bolus for 10 minutes followed by the infusion of 0.1-1 ug/kg/h during general anesthesia
remifentanil iv infusion of 0.5-5 ng/ml (effect site concentration using TCI) during general anesthesia
DRUGLidocaine Hydrochloride
lidocaine iv bolus followed by the infusion of 1.5mg/kg/h during general anesthesia
Sponsors
The Catholic University of Korea
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* patients scheduled for elective gynecological laparoscopy
Exclusion criteria
* emergent surgery * cancer surgery * chronic pain requiring pain killers * psychiatric disease * preoperative bradycardia (HR \< 50 bpm) * allergies * pregnancy or breast feeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| postoperative pain in recovery room | 30 minuetes after the completion of surgery | The pain level is assessed by using NRS (numeric rating scale; 0=no pain , 10=the worst pain) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| shivering in recovery room | 30 minuetes after the completion of surgery | The incidence of shivering is assessed by questioning Yes or No. |
| postoperative nausea and vomiting (PONV) | 30 minutes after the completion of surgery | The incidence of PONV is assessed by questioning Yes or No |
Countries
South Korea
Outcome results
None listed