Evaluation of the New Variant 501Y.V2 of COVID-19

Comparison of Mortality in Severe SARS-Cov-2 Infection Caused by the 501Y.V2 Variant and B.1.1.7 Variant

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04906850

Acronym

VARICOVID

Enrollment

250

Registered

2021-05-28

Start date

2021-03-01

Completion date

2021-05-15

Last updated

2021-06-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Covid19

Keywords

Mortality, SARS-CoV-2 variants, Intensive Care Unit, 20I/501Y.V1, 20H/501Y.V2

Brief summary

In January 2021, the incidence of COVID-19-and its mortality started rising for the third time in France. This rise may associate with three emerging variants, namely, V1, V2, and V3, which are the 20I/501Y.V1 (English), 20H/501Y.V2 (South African), and 20J/501Y.V3 (Brazilian) variants, respectively. V1 was recently suggested to increase mortality in people in the United Kingdom who tested positive for COVID-19 on community screening. Very little is known about V2 infection, including its outcomes relative to other strains. In early 2021, V2 spread to the Grand-Est region (northeastern France). Here, the investigators aimed to report mortality data of patients admitted in ICU between February and April 2021 in 3 hospitals in Grand-Est: Metz, Thionville and Nancy.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Admission in ICU in February, March or April 2021 * Patient with a SARS-CoV-2 positive polymerase-chain reaction test * Patient with 20I/501Y.V1 (English) or 20H/501Y.V2 (South African) SARS-CoV-2 variants

Exclusion criteria

* Opposed to use data

Design outcomes

Primary

Measure	Time frame	Description
Mortality 28 days after admission	Day 28	Vital status 28 days after admission in Intensive Care Unit

Secondary

Measure	Time frame	Description
ICU mortality	Day 1	Percentage of mortality in Intensive Care Unit

Countries

France

Outcome results