Anesthesia; Reaction
Conditions
Brief summary
We aim to compare the response to ketamine/dexmedetomidine and ketamine/propofol combinations used in hepatic patients with child-Pugh classification (class A), and early (class B) undergoing UGIE.
Detailed description
70 Patients will be randomly allocated into two groups; Group (KD): Ketamine/dexmedetomidine (35 patients), will receive IV ketamine 0.25mg/kg and dexmedetomidine1µg/kg over 10 min as loading followed by dexmedetomidine infusion with a rate of 0.5µg/kg/hr and Group (KP): ketamine/propofol (35 patients) will receive IV ketamine 0.25 mg/kg loading and propofol 1 mg/kg over 10 min followed by propofol infusion with a rate of 0.5 mg/kg/hr as a control group.
Interventions
DRUGDexmedetomidine
participants received loading of ketamine 1 mg/kg and dexmedetomidine 1µg/kg over 10 minutes then continue by a dose of 0.25 mg/kg/hr ketamine and 0.25µg/kg/hr dexmedetomidine throughout the procedure.
DRUGPropofol
participants received loading of ketamine 1 mg/kg and propofol 1mg/kg over 10 minutes then continue by a dose of 0.25 mg/kg/hr propofol and 0.25µg/kg/hr dexmedetomidine throughout the procedure.
Sponsors
Tamer Nabil Abdelrahman
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* hepatic patients with child-Pugh classification (class A), and (class B) * American Society of Anesthesiologists physical status II, III * aged 18 to 60 years * scheduled for elective Upper gastro-intestinal endoscopy.
Exclusion criteria
* emergency gastro-intestinal endoscopy. * patients with severe hepatic disorder (Child C) , * chronic neuro-psychiatric disorder, * history of neuro-psychiatric drug intake, * severe cardiovascular diseases, * pregnancy, * history of drug abuse, and * history of allergy to any of the used drugs in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| induction time | after 5 minutes from the start of drug infusion till target Ramsay Sedation Score ≥ 3 is reached | Time to reach target Ramsay Sedation Score ≥ 3 |
| Recovery time | after 10 minutes from the stoppage of drug infusion at the end of the procedure till spontaneous eye opening | time from the stoppage of drug infusion at the end of the procedure till spontaneous eye opening |
Countries
Egypt
Outcome results
None listed