Effects of Body Position on Diaphragmatic Activity in Patients Requiring Noninvasive Ventilation for Acute Respiratory Failure COVID-19 Related

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04904731

Acronym

DiaCOVIDProne

Enrollment

Registered

2021-05-27

Start date

2021-02-19

Completion date

2021-05-24

Last updated

2021-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19 Respiratory Infection, Diaphragm Injury, Noninvasive Ventlation

Brief summary

The present investigation aims to assess the diaphragmatic thickening fraction, reflecting the diaphragmatic activity, during supine (baseline) and at 1 hour following prone position in patients assisted through non invasive ventilation due to hypoxemic acute respiratory failure related to COVID-19. Also, the impact of lung aeration and comfort were ascertained in the same setting

Detailed description

Primary aim is to asses the effects of body position on diaphragmatic thickening fraction (primary aim) and lung aeration and vital sign (secondary aims) in patents assisted via noninvasive ventilation (NIV) for hypoxemic acute respiratory failure (hARF) associated to COVID-19. All adult patients, admitted for hARF due to COVID-19 and requiring NIV were enrolled. Diaphragmatic thickening fraction, lung aeration assessed through ultrasound, comfort, and grade of sedation-agitation as well as vital signs, i.e., peripheral oxygen saturation, blood pressure, and breathing pattern were monitored during noninvasive ventilation in supine and after 1 hour following the switch to prone position.

Interventions

OTHERProne position

Patients were assisted in NIV in supine position that was switched in prone position for clinical purpouse

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* COVID-19 infection, * Age \> 18 years, * NIV application, * ICU admission

Exclusion criteria

* Pregnancy, * All the conditions contraindicating prone position and NIV

Design outcomes

Primary

Measure	Time frame	Description
Diaphragmatic thickening fraction	At baseline, in supine position	The fraction of diaphragmatic thickness variations during respiratory cycle

Secondary

Measure	Time frame	Description
Lung aeration	At baseline, in supine position	Lung aeration assessed through sonography
Peripheral oxygen saturation	At baseline, in supine position	Reflects the grade of peripheral oxygenation

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 21, 2026