Stroke
Conditions
Brief summary
This study is to investigate the effect of transcranial direct current stimulation (tDCS) simulation on motor learning to stroke patients compared to sham stimulation
Interventions
DEVICETranscranial Direct Current Stimulation
Transcranial direct current stimulation is a form of noninvasive neuromodulation that uses constant and low direct current delivered via electrodes on the scalp.
BEHAVIORALMotor learning
Sequential finger tapping task training is applied to stroke patients.
Sponsors
Samsung Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Unilateral stroke including basal ganglia lesion patients * Chronic patients over 6 months after onset * Patients with the movement of fingers
Exclusion criteria
* History of psychiatric disease * Significant other neurological diseases except for stroke * Difficult to perform this experiment * Patients who are deemed difficult to participate in this research by the investigator * Patients with metal implants and medical devices * History of epilepsy * Pregnancy * Skin defect at the site of electrode attachment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fugl-Meyer Assessment | Baseline, immediately after five brain stimulation sessions | The score is a stroke-specific, performance-based impairment index. The degree of impairment of upper and lower limbs is measured. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in cortical activity using fNIRS signals during brain stimulation | Baseline, during, immediately after five brain stimulation sessions | Cortical activities before, during and after brain stimulation sessions are compared. |
| Changes in motor evoked potential | Baseline, immediately after five brain stimulation sessions | Resting motor threshold (rMT) and amplitude of motor evoked potential in first dorsal interosseous muscle are measured. These outcomes are measured by transcranial magnetic stimulation over the motor hotspot. The rMT is defined as the minimum stimulus intensity that produced a minimal motor evoked response at rest. The amplitude means peak to peak of the muscle response. |
| 9-hole pegboard test | Baseline, immediately after five brain stimulation sessions | The test is a standardized, quantitative assessment used to measure finger dexterity of a patient. |
| Grip & Tip pinch strength test | Baseline, immediately after five brain stimulation sessions | The test is to measure the maximum isometric strength of hand, forearm, and finger muscles. |
| Sequential Finger tapping test | Baseline, immediately after five brain stimulation sessions | Response time is measured during sequential finger tapping task. |
| Jebsen-Taylor hand function test | Baseline, immediately after five brain stimulation sessions | This test is a standardized and objective measure of fine and gross motor hand function using simulated activities of daily living (ADL). |
| Box & Block test | Baseline, immediately after five brain stimulation sessions | The test is used to measure the gross manual dexterity of a patient, or of a person using an upper limb prosthetic device. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Resting-state functional MRI | Baseline (Before stimulation sessions) | Before intervention, MRI is acquired to extract brain characteristics of stroke patients. |
| Changes in cortical activity using fNIRS signals. | Baseline (Before stimulation sessions) | Before intervention, fNIRS image is acquired to extract cortical activation of stroke patients. |
Countries
South Korea
Outcome results
None listed