ACL Injury
Conditions
Brief summary
The aim of this pilot study is to understand the biological changes that occur within the knee joint following injury to the anterior cruciate ligament (ACL). This will be achieved through aspiration and analysis of the haemarthrosis which fills the knee following injury. The study will look at inflammatory and healing responses using DNA, RNA and protein analysis. This, combined with high resolution imaging of the knee and surrounding soft tissue structures, may enable a more patient specific approach to treatment of ACL injury.
Interventions
DIAGNOSTIC_TESTAspiration of haemarthrosis and high definition MRI
Aspiration of haemarthrosis and high definition MRI
Sponsors
Cambridge University Hospitals NHS Foundation Trust
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of ACL injury confirmed by MRI * All participants must have the capacity to provide informed consent to participate * Participants must be able to comply with required study visit
Exclusion criteria
* Participants outside of the specified age range * Participants who do not have the mental capacity to make informed decisions * Participants who have meniscal pathology or other injuries requiring urgent surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pattern of injury on High Definition MRI measured by comparison with 3t MRI images | Last visit, usually 28 days | Outcome will illustrate any additional benefit of high definition MRI |
Secondary
| Measure | Time frame |
|---|---|
| Identification of acute inflammatory mediators measured by NanoString molecular analysis | Last visit, usually 28 days |
Countries
United Kingdom
Contacts
Primary ContactStephen McDonnell
Backup ContactJenny O'Callaghan
Outcome results
None listed