Traumatic Brain Injury
Conditions
Keywords
Brain Injuries, Traumatic, Aerobic Exercise, Leg Cycling, Virtual Reality
Brief summary
Aerobic exercise is a promising treatment modality for cognition in persons with TBI, but effects are consistently small. This study aims to investigate the effect of difference environments during moderate intensity cycling sessions on cognition.
Detailed description
The proposed research study would be the first to investigate the acute effects of aerobic exercise with different environments relative to control and comparison conditions on several domains of cognition in people with TBI. This critical investigation will be a first step toward systematically identifying an optimal exercise training intervention for managing common cognitive consequences of TBI.
Interventions
BEHAVIORALExercise Only
Cycling in a lab environment
BEHAVIORALExercise + Non-Immersive Virtual Reality
Cycling with an environment simulated by non-immersive virtual reality
BEHAVIORALExercise + Immersive Virtual Reality
Cycling with an environment simulated by immersive virtual reality
Sponsors
Kessler Foundation
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Masking description
The PI will be blinded to the order of conditions for each participant.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Be at least 18 years of age and younger than 59 years of age * Speak English as their primary language * Have had a previous TBI at least one year prior\\
Exclusion criteria
* Have contraindications to moderate or high intensity physical activity, based on the Physical Activity Readiness Questionnaire (PAR-Q) * Have a history of psychiatric illness (ex: major depression, bipolar disorder, schizophrenia), neurological disorders beyond TBI (ex: stroke, seizure disorder), or substance abuse * Currently use medications that might impact cognition (ex: steroids, benzodiazepines, neuroleptics) * Be currently pregnant * Have visual impairments not otherwise corrected by contact lenses (ex: stereo blindness, colorblindness) * Have a high likelihood of motion sickness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change on Walking While Talking Test (WWT) | 30 minutes (before and after the acute exercise intervention) | The WWT measures multitasking by comparing performance on a single motor task to the motor performance during a simultaneous motor + cognitive dual task. |
| Change on N-Back Test (N-back) | 30 minutes (before and after the acute exercise intervention) | The N-Back is a measure that requires participants to listen to a sequence of numbers and decide if the current number is the same as the one presented N trials ago. |
| Change on the Modified Flanker Test (MFT) | 30 minutes (before and after the acute exercise intervention) | This task requires individuals to correctly respond to a target symbol amid other symbols, ignoring irrelevant information. |
Countries
United States
Outcome results
None listed