Anterior Chamber Inflammation, Cornea, Refractive Surgery
Conditions
Keywords
Excimer laser Corneal Endothelium, Laser in situ keratomileusis (LASIK);, femtosecond assisted-LASIK, Anterior chamber flare, Endothelial cell densit, Corneal Endothelium
Brief summary
This study aimed to investigate whether femtosecond laser-assisted LASIK (FS-LASIK) surgery causes inflammation in the anterior chamber and to analyze its effect on endothelial cells.
Detailed description
Since FS-LASIK surgery is applied using both an FS laser and an excimer laser, we aimed to determine the direct and indirect effects of these applications on the corneal endothelium, the intensity of the inflammation, and the blood-aqueous barrier in the anterior chamber. To the best of our knowledge, the effects of FS-LASIK on anterior chamber inflammation have not been previously investigated. Therefore, we evaluated these effects using objective measurement methods, such as specular microscopy and laser flare photometry.
Interventions
PROCEDUREFemtosecond laser assisted LASIK
Refractive surgery
Sponsors
Istanbul University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Masking description
Patients name and identifiers were masked
Intervention model description
prospective, before-after study
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* The patients who performed Femtosecond laser assisted LASIK for myopia or myopic astigmatism. * Uncomplicated surgery
Exclusion criteria
* Complicated surgery, * Hyperopic or hyperopic astigmatism * Lack of follow-up measurements
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of Flare Values | The change of flare values on first day, seventh day, 1. month and 3. months according to preoperative values | To measure anterior chamber inflammation objectively, Flare values were measured by the laser flare-photometry |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of Corneal endothelium features-1 | the changes of the parameters of preoperative and 3. months' values | Endothelial cell density (ECD),(The parameter was measured by specular microscopy) |
Other
| Measure | Time frame | Description |
|---|---|---|
| Change of Corneal endothelium features-2 | the changes of the parameters of preoperative and 3. months' values | Coefficient of Varience (CV) in cell size, (The parameter was measured by specular microscopy) |
| Change of Corneal endothelium features-3 | the changes of the parameters of preoperative and 3. months' values | Hexagonality percent of the cell shape. (The parameter was measured by specular microscopy) |
Countries
Turkey (Türkiye)
Outcome results
None listed