Kidney Transplantation
Conditions
Brief summary
The purpose of this study is to validate an MRI method to detect renal fibrosis in patients after kidney transplantation (KT).
Detailed description
The hypothesis underlying this proposal is that qMT reliably detects development of allograft fibrosis in human subjects after KT. To test this hypothesis, the qMT-derived bound pool fraction will be correlated with renal fibrosis as per biopsy in 20 patients 4 or 7 years after living donor KT. The bound pool fraction will also be compared to renal blood flow, oxygenation, and function, and the ability of qMT to provide consistent assessments of fibrosis tested at different magnetic field strengths. Two specific aims will test the hypotheses that: Specific Aim 1: qMT provides reliable and consequential assessment of fibrosis in human kidney allografts. Specific Aim 2: Renal fibrosis assessed by qMT in human kidney allografts is reproducible at 1.5 T and 3.0 T.
Interventions
OTHERMRI 1.5T and 3.0T
Magnetic Resonance Imaging for Renal Fibrosis
Sponsors
National Institute on Aging (NIA)
Mayo Clinic
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Prospective, unblinded, Parallel, imaging study
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-80 years * Recipient of living donor kidney transplantation 4 or 7 years earlier * Competent and able to provide written informed consent; Ability to comply with protocol
Exclusion criteria
* Patients have clinically significant medical conditions within the prior 6 months before: e.g. myocardial infarction, congestive heart failure, stroke, that would, in the opinion of the investigators, compromise the safety of the patient. * Severe chronic liver, heart or lung disease * Undergoing acute rejection * Contra-indication to biopsy; bleeding disorders * Chronic infection * Any active malignancy and undergoing therapy * Kidney or ureteric stone * Unable to give valid informed consent * Known pregnancy or intent to conceive during the study period * Pacemaker, implantable defibrillator, magnetically active metal fragments, claustrophobia or other contraindication to MRI * Federal medical center inmates. * Latex allergy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The values and correlation of f with IF | 2 years | Correlation of qMT with tissue fibrosis (trichrome) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The correlation of f with renal function attributes and pro-fibrogenic activity | 2 years | Correlation of qMT with renal oxygenation, GFR, levels of fibrogenic factors. |
Countries
United States
Outcome results
None listed