Covid-19 Vaccine
Conditions
Brief summary
Since the first local case of COVID-19 confirmed on 4 Feb 2020, Hong Kong has already experienced 4 waves of COVID-19 surge, with more than 9000 cases reported. A number of vaccines have been shown to be efficacious against symptomatic and severe infection by inducing neutralizing antibody (NAB) against spike protein of the SARS-CoV-2 virus. However, the duration of protection and longevity of antibody response is unknown. Health care workers (HCWs) who are planning to receive COVID-19 vaccine will be recruited. The level of antibody against spike protein by different quantitative assays will also be serially measured .
Interventions
BIOLOGICALCoronaVac Vaccine
CoronaVac Vaccine
BIOLOGICALBNT162b2 Vaccine
Covid-19 BNT162b2 Vaccine
Sponsors
Hong Kong Sanatorium & Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
1. Any staff, visiting doctor, nursing student of HKSH who are aged 18 or above 2. No contraindication for COVID-19 vaccination and plan to receive the intended dosages at the appropriate interval. 3. A baseline serology taken within 1 week before vaccination shows no evidence of recent infection. 4. No history of documented COVID-19 infection
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of IgG Level in the serum of healthcare workers who received COVID-19 vaccine | 1 month, 3 months and 6 months post vaccination | Change of IgG Level in the serum of healthcare workers who received COVID-19 vaccine at different points during the first six months of vaccination |
Countries
Hong Kong
Outcome results
None listed