Arterial Stiffness, Healthy Ageing, Microvascular Circulation, Vascular Endothelium
Conditions
Brief summary
The greatest challenge in our ageing society are cardiovascular diseases such as stroke, heart attack, peripheral artery disease of the legs with non-healing wounds (ulcers), or diabetes. How healthy ageing affects the smallest blood vessels (microcirculation) and is not well understood. One reason for this is that no generally available medical instrument has the resolution to study the microcirculation. The recently developed optical coherence tomography angiography (OCTA), currently mainly used by eye doctors, is able to visualise the microcirculation. We have developed an automated software (OCTAVA) to determine metrics to characterise the microcirculation on the layers of density, diameter and tortuosity. In the current study we aim at providing reference values of these metrics in hands and feet of healthy people according to age together with macrovascular function in arms and legs.
Interventions
OTHERAge
Determination of age-dependence
Sponsors
University of Surrey
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy, 20-70 years, BMI 20-30 kg/m\^2
Exclusion criteria
Diabetes mellitus, symptoms of acute infection, cardiac arrhythmias, active malignancy, clinical signs or symptoms of cardiovascular disease (coronary artery disease, lower extremity artery disease, cerebrovascular disease): angina pectoris, dyspnea, palpitation, syncope, claudication, active vasoactive medication.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Microvascular density | 1 day (One timepoint during single visit) | Density of skin microvasculature of hand and foot with OCTA at rest and after 5 min distal occlusion |
| Microvascular diameter | 1 day (One timepoint during single visit) | Diameter of skin microvasculature of hand and foot with OCTA at rest and after 5 min distal occlusion |
| Microvascular turtuosity | 1 day (One timepoint during single visit) | Turtuosity of skin microvasculature of hand and foot with OCTA at rest and after 5 min distal occlusion |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood pressure | 1 day (One timepoint during single visit) | Upper arm blood pressure and leg systolic blood pressure |
| Endothelial function | 1 day (One timepoint during single visit) | Flow-mediated dilation of brachial and common femoral artery with ultrasound |
| Arterial stiffness | 1 day (One timepoint during single visit) | Pulse wave velocity measured at upper arm (Arteriograph) |
Countries
United Kingdom
Contacts
Primary ContactChristian Heiss, Prof.
Backup ContactDanuta Sampson, Dr.
Outcome results
None listed