Malnutrition, Child
Conditions
Keywords
malnutrition, whole egg consumption, primary school student, growth
Brief summary
This research compares the effects of one-year continuous whole egg supplement vs. egg yolk substitutes and control on anthropometry, biochemical blood parameters, metabolic enzymes and microbiome data in primary school children.
Detailed description
This research study determine the long-term effects of egg supplementation on growth, blood lipoproteins, blood proteins, nutritional status, metabolic enzymes and microbiomes in children, enrolling in the school lunch program.
Interventions
DIETARY_SUPPLEMENTwhole eggs
whole eggs
DIETARY_SUPPLEMENTyolk-free egg substitutes
yolk-free egg substitutes
Sponsors
Mahidol University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Caregiver, Investigator, Outcomes Assessor)
Intervention model description
A randomized controlled cluster trial
Eligibility
Sex/Gender
ALL
Age
8 Years to 14 Years
Healthy volunteers
Yes
Inclusion criteria
1\. Aged between 8-14 years
Exclusion criteria
1. Allergic of eggs 2. People who cannot continue to follow up the protocol 4\. Having contra-indication i.e. problems with blood clotting
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| changes in body weight following the dietary intervention | week 0 (baseline), week 13 - 14, week 34 - 35 | weight (kg), weight for age (z-score) analysis |
| changes in height following the dietary intervention | week 0 (baseline), week 13 - 14, week 34 - 35 | height (cm), height for age (z-score) analysis |
| change in blood protein levels following dietary intervention | week 0 (baseline), week 13 - 14, week 34 - 35 | transferrin (mg/dl), pre-albumin (mg/dl), albumin (g/dl) analysis |
| changes in blood biochemistries following dietary intervention | week 0 (baseline), week 13 - 14, week 34 - 35 | fasting blood sugar (mg/dl), cholesterol (mg/dl), triglyceride (mg/dl), HDL-Cholesterol (mg/dl), LDL-Cholesterol (mg/dl) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| changes in microbioma and stool metabolites following dietary intervention | week 0 (baseline), week 13 - 14, week 34 - 35 | bacterial type, fatty acids in stool |
| changes in blood biochemistries following dietary intervention metabolite enzyme | week 0 (baseline), week 13 - 14, week 34 - 35 | lecithin-cholesterol acyltransferase (LCAT), cholesterol ester transfer protein (CETP), apolipoprotein C (APOC), apolipoprotein E (APOE) |
Countries
Thailand
Outcome results
None listed