Breast Cancer, Cancer, Cardiotoxicity, Esophageal Cancer, Lung Cancer, Radiotherapy; Complications
Conditions
Brief summary
The purpose of this study is to evaluate and compare the changes by two modalities: Imaging by Strain by Speckle Tracking and Magnetic Resonance versus soluble markers of cardiac dysfunction as early predictors of cardio-toxicity in cancer patients receiving low or high doses of radiotherapy.
Interventions
None listed
Sponsors
Pontificia Universidad Catolica de Chile
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ≥18 year-old patients * With histologically confirmed thoracic cancer (breast, esophagus or lung) * Recommendation of thoracic radiotherapy (RT) with curative intent * With or without chemotherapy * All patients must be able to read and understand Spanish * All patients must sign informed consent form.
Exclusion criteria
* Patients with no medical records, * Pregnant * Previously diagnosed with severe left ventricular dysfunction or a cardiac insufficiency * Patients with metastatic disease and indication of palliative RT * Patients with significant comorbidities associated to a \<5 year life expectancy. * Patients previously treated with thoracic RT
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Global Longitudinal Strain (Left Ventricle) | Baseline, 1 and 12 weeks after Treatment | \>5 Absolute drop or 12% Relative reduction from baseline |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cardiac Magnetic Resonance Anatomical Image | Baseline, 1 and 12 weeks after treatment | Inversion recovery single shot balance 3D short axis covering the entire heart and aorta with free respiratory trigger |
| Cardiac Magnetic Resonance Cinema Imaging | Baseline, 1 and 12 weeks after treatment | Cinema imaging: Long axis balance, Balance 4 cameras, Short shaft full balance, Right ventricular balance |
| Cardiac Magnetic Resonance Flow Image | Baseline, 1 and 12 weeks after treatment | 2D outflow tract of the aorta 2D pulmonary artery outflow tract |
| Cardiac Magnetic Resonance Quantitative Image | Baseline, 1 and 12 weeks after treatment | T1 map short axis apical section T1 map short axis medial section T1 map short axis basal section T2 map short axis apical section T2 map short axis medial section T2 map short axis basal section |
Other
| Measure | Time frame | Description |
|---|---|---|
| Circulating Endothelial Cells | Baseline, 1 and 12 weeks after treatment | Number of Circulating Endothelial Cells |
| N-Terminal pro-Brain Natriuretic Peptide | Baseline, 1 and 12 weeks after treatment | N-Terminal pro-Brain Natriuretic Peptide, rises \>99%th percentile of the upper reference limit |
| High-sensitivity Cardiac Troponin-T | Baseline, 1 and 12 weeks after treatment | Troponin rises \>99%th percentile of the upper reference limit |
Countries
Chile
Outcome results
None listed