Non-obstructive Azoospermia, Obstetric Complication, Obstructive Azoospermia
Conditions
Keywords
Reproductive outcomes
Brief summary
A comparison of reproductive and obstetrical outcomes is retrospectively performed among couples that underwent ICSI-TESE cycles for obstructive and non obstructive azoospermia between January 2001 and December 2019.
Detailed description
Azoospermia affects almost 20% of all infertile males and It can be divided into obstructive azoospermia (OA) and nonobstructive azoospermia (NOA). Assisted fertilization with testicular sperm extraction (TESE) and intracytoplasmatic sperm injection (ICSI) has been successfully applied for its treatment. Review of the literature shows that there is a lack of consensus about reproductive outcomes between men with OA and NOA. No study has ever investigated differences in obstetrical outcomes between these two groups before. The objective of this study is to retrospectively determine differences in reproductive and obstetrical outcomes among couples that underwent ICSI-TESE cycles for obstructive and non obstructive azoospermia. The primary outcomes that will be investigated include: * Reproductive outcomes: pregnancy rate, live birth rate (LBR) and abortion rate. * Obstetrical outcomes: twinning rate, gestational age, prematurity rate, birth weight, cesarean section rate and the rate of the main obstetrical complication, such as pre-eclampsia, gestational hypertension, intrauterine growth restriction (IUGR).
Interventions
PROCEDUREICSI-TESE; embryo-transfer
The sperm injected into the cytoplasm of an oocyte (Intracytoplasmatic Sperm Injection) is obtained by testicular extraction. Ultrasound guided transvaginal embryo transfer.
Sponsors
Istituto Clinico Humanitas
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
for obstructive azoospermia group: * infertility * diagnosis of obstructive azoospermia * ICSI-TESE cycles Inclusion Criteria for non-obstructive azoospermia group: * infertility * diagnosis of non-obstructive azoospermia * ICSI-TESE cycles
Exclusion criteria
* Sperm donation * Use of ejaculated sperm * Couples who underwent pre-implantation genetic testing
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Live birth rate (LBR) | 20 years (2001-2019) | Rate of delivery of a living baby after at least 22 weeks of gestation |
| Pregnancy rate | 20 years (2001-2019) | Total number of pregnancies including live births, abortions and fetal death |
| Abortion rate | 20 years (2001-2019) | Proportion of clinical pregnancies who failed to continue beyond 22 weeks of gestation |
| Maternal complications rate | 20 years (2001-2019) | Incidence of the obstetric complications, such as pre-eclampsia, gestational hypertension, placenta previa and placental abruption, intrauterine growth restriction. |
| Gestational age | 20 years (2001-2019) | Mean gestational age of the pregnancies considered (written with both weeks and days) |
| Prematurity rate | 20 years (2001-2019) | Rate of pregnancies lasted less than 37 weeks and 0 days |
| Twinning rate | 20 years (2001-2019) | Rate of twin deliveries out of the total number of deliveries |
| Cesarean section rate | 20 years (2001-2019) | Rate of cesarean section deliveries out of the total number of deliveries |
| Birth weight | 20 years (2001-2019) | Mean birth weight of the neonates written in grams. |
Outcome results
None listed