Covid19
Conditions
Brief summary
It is to explore the temporal relationships between physical fitness, cognitive, psychosocial functions, and health-related quality of life (HRQoL) in COVID-19 survivors over the first 15 months; and to determine the effects of centre-based (CBR), online-based cardiopulmonary rehabilitation (OBR), and combined centre- and online-based rehabilitation (COBR) on survivors with initially suboptimal pulmonary functions.
Interventions
OTHERCardiopulmonary exercise (centre-based)
Depending on the preference of participants, they can either choose to join three 60-minute centre-based sessions plus two sessions of 30-minute home exercise per week, or two 60-minute centre-based sessions plus four sessions of 30-minute home exercise per week. Each session will include warm-up and cool-down exercises, aerobic exercises, and progressive strengthening exercises prescribed based on individual ability (Table 1). Aerobic exercises will be performed at 60-75% (up to 85% for fit individuals) of the predicted maximum heart rate. The respective rate of perceived exertion during exercise will be maintained between 4 and 6 out of 10 on the Borg CR scale \[10\], indicating moderate to strenuous exercise levels. Additionally, physiotherapists will provide education related to COVID-19, energy conservation, and stress management during the program.
OTHERCardiopulmonary exercise (online-based)
Participants in the OBR group will attend one face-to-face session to learn how to use a mobile application (app) followed by 6 weeks of home exercises. The online treatments will be delivered via the Caspar Health e-system, a German-designed Internet-based system, is available for desktop PCs and as a mobile app for both iOS and Android smartphones. This system will enable patients to follow their therapists' treatment plans in an asynchronous manner. The OBR programme will last for 6 weeks. Participants will be instructed to perform 40 minutes of structured exercises 6 times per week. In the first week, six 40-minute online exercise sessions will be delivered through push notifications on the mobile app.
Sponsors
Pamela Youde Nethersole Eastern Hospital, Hong Kong
Queen Elizabeth Hospital, Hong Kong
Princess Margaret Hospital, Hong Kong
Tuen Mun Hospital Hong Kong
The Hong Kong Polytechnic University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* COVID survivor at hospital discharge or 6-month post-disease onset * Medically stable with an Abbreviated Mental Test (AMT) scores of \> 6 out of 10
Exclusion criteria
* Having contraindications to exercise * Physical Activity Readiness Questionnaire (PAR-Q) reveals unsafety * Cannot understand Cantonese
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fatigue measured by Fatigue Assessment Scale | 6 weeks after the start of intervention | The Fatigue Assessment Scale is a 10-item scale evaluating symptoms of chronic fatigue.exercise test. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Self-efficacy by 6-Item Chronic Disease Self-Efficacy scale | Baseline | A six-item digital self-administered self-efficacy questionnaire will be used to evaluate patients' confidence in performing exercise, managing their own symptoms and emotions and completing their daily tasks. |
| Self-perceived quality of life by The St. George's Respiratory Questionnaire-HK version | Baseline | The St. George's Respiratory Questionnaire-HK version is a self-reported questionnaire. This 50-item disease specific questionnaire assesses 3 domains (symptoms, activity, and impacts). |
| Self-perceived quality of life by The Hong Kong Chinese version Short Form-36 | Baseline | The Hong Kong Chinese version Short Form-36 is a concise 36-item health status questionnaire with good psychometric properties. |
| Cardiac output (L/min) | Baseline | Non-invasive electrodes will be placed on the clavicle and lateral side of chest wall by a non-invasive measurement of cardiac output using the CardioScreen 1000 System. Non-invasive electrodes will be placed on the clavicle and lateral side of chest wall bilaterally |
| Cardiac stroke volume (ml/m2) | Baseline | Non-invasive electrodes will be placed on the clavicle and lateral side of chest wall by a non-invasive measurement of cardiac output using the CardioScreen 1000 System. Non-invasive electrodes will be placed on the clavicle and lateral side of chest wall bilaterally |
| Muscle strength by 30-second double-leg sit-to-stand test (times) | Baseline | Muscle strength will be assessed with the 30-second double-leg sit-to-stand test. If the participant can perform the 30-second single leg sit-to-stand test with pain or difficulty, they will be invited to complete 30-second single-leg sit-to-stand test. The number of completed repetitions will be counted. |
| Forced vital capacity (l) | Baseline | Forced vital capacity (FVC) is the volume of air that can forcibly be blown out after full inspiration |
| FEV1/FVC | Baseline | Ratio of forced expiratory volume in one second and forced vital capacity |
| Peak expiratory flow rate (l/s) | Baseline | Peak expiratory flow (PEF) is the maximal flow (or speed) achieved during the maximally forced expiration initiated at full inspiration |
| Exercise capacity (m) | Baseline | Exercise capacity will be assessed by the 6-minute walk test (6MWT), a submaximal exercise test. |
| Forced expiratory volume in one second (l) | Baseline | FEV1 is the volume of air that can forcibly be blown out in first 1 second, after full inspiration |
Countries
Hong Kong
Contacts
Primary ContactSiu Ngor Fu, PhD
Outcome results
None listed