Diabetes, Periodontitis
Conditions
Keywords
Diabetes,, periodontitis, cytokines
Brief summary
Type 2 diabetes mellitus is a metabolic disorder. There is a bidirectional association between periodontal disease and DM. Currently there is no data relationship between CSF-1 and IL-34, periodontal disease and diabetes.The aim of this study to investigate GCF levels of IL-34 and CSF-1 in periodontitis subjects with diabetes.
Detailed description
Periodontally healthy (H), periodontitis, and periodontitis with diabetes patients, were recruited for this study. 1. Inclusion criteria for H groups: Individuals with clinically healthy gingiva, no attachment and bone loss, and less than 10% bleeding on probing were included. 2. Inclusion criteria for periodontitis groups: Systemically healthy individuals with interdental CAL ≥ 5 mm and PPD ≥ 6 mm were included. 3. Inclusion criteria for periodontitis with diabetes groups: Type 2 diabetes patients with interdental CAL ≥ 5 mm, PPD ≥ 6 mm, and HbA1c ≥ 6.5% were included. The plaque index (PI), gingival index (GI), presence of bleeding on probing (BOP), PD, and clinical AL were used for clinical periodontal assessments. All assessments were done with a manual probe. GCF samples were obtained and analyzed using an enzyme-linked immunosorbent assay.
Interventions
DIAGNOSTIC_TESTGingival crevicular fluid
GCF samples were collected in the morning hours 24-48 hours after clinical periodontal measurement.
Sponsors
Uşak University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* have 20 teeth * have diabetes .
Exclusion criteria
* Individuals have systemic disease * smokers; * pregnant * those using drugs;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| It was aimed to compare IL-34 levels by taking gingival crevicular fluid in systemic healthy, periodontitis and diabetic patients with periodontitis groups. | GCF samples taken within the 1. week after the clinical examination of the patient | GCF was taken interproximal region. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| It was aimed to compare CSF-1 levels by taking gingival crevicular fluid in systemic healthy, periodontitis and diabetic patients with periodontitis groups. | GCF samples taken within the 1. week after the clinical examination of the patient | GCF was taken interproximal region. |
Countries
Turkey (Türkiye)
Outcome results
None listed