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Resting Heart Rate in Chronic Obstructive Pulmonary Disease

Improvement of Resting Heart Rate After Exercise Training and Its Predictors in Chronic Obstructive Pulmonary Diseases

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04890080
Enrollment
110
Registered
2021-05-18
Start date
2017-01-31
Completion date
2021-04-30
Last updated
2021-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COPD, Exercise, Pulmonary Rehabilitation, Resting Heart Rate

Keywords

resting heart rate, COPD, exercise, pulmonary rehabilitation

Brief summary

110 COPD patients who were participated in the PR program were included in the study. Resting Heart Rate , pulmonary functions, functional capacity, perception of dyspnea, quality of life and psychological symptoms compared before and after PR.

Detailed description

In many studies, it has been reported that baroreceptor activity and heart rate variability decrease and resting heart rate (RHR) increases in COPD patients due to changes in cardiac autonomic function. Among the recommendations regarding pulmonary rehabilitation (PR) and exercise training in COPD patients, approaches such as including practices targeting RHR and developing implementation strategies that improve the cardiovascular system are recommended. The primary aim of our study is to examine the effect of comprehensive exercise training consisting of breathing, aerobic and strengthening exercises on RHR in COPD patients, and secondarily to determine the factors that affect RHR change after PR in COPD patients. 110 COPD patients who were participated in the PR program were included in our retrospective study. Resting Heart Rate , pulmonary functions, functional capacity, perception of dyspnea, quality of life and psychological symptoms compared before and after PR.

Interventions

OTHERPulmonary Rehabilitation

Exercise training consisted of supervised breathing, aerobic, strengthening and stretching exercises for 8 weeks, 2 days a week. Breathing exercises included pursed lip, diaphragmatic, thoracic expansion and basal expansion exercises. Strength training included the lower and upper extremities, and it was performed 8-10 repetitions, either against gravity or using free weight, according to patient tolerance.

Sponsors

Izmir Katip Celebi University
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Patients diagnosed with COPD according to GOLD and completed the 2-day / 8-week PR program

Exclusion criteria

* With cardiovascular disease * With additional diseases such as diabetes * Receiving medical treatment that affects the autonomic nervous system * Patients receiving long-term oxygen therapy

Design outcomes

Primary

MeasureTime frameDescription
Resting Heart Rate1 minutenumber of beats per minute

Secondary

MeasureTime frameDescription
Functional CapacityChange from baseline six minute walk distance at 8 weekSix Minute- walk test
Dyspnea AssessmentChange from baseline dyspnea at 8 weekMedical Research Council Scale(MRC); the MRC dyspnea scale is a questionnaire that consists of five statements about perceived breathlessness. (min 1- max 5 point) Higher scores mean a worse outcome.
Quality of Life AssessmentChange from baseline dyspnea at 8 weekSt. George Respiratory Questionnaire; Scores range from 0 to 100, with higher scores indicating more limitations.
Anxiety and DepressionChange from baseline dyspnea at 8 weekHospital Anxiety and Depression (HAD); The HADS questionnaire has seven items each for depression and anxiety subscales. Scoring for each item ranges from zero to three, with three denoting highest anxiety or depression level. A total subscale score of \>8 points out of a possible 21 denotes considerable symptoms of anxiety or depression.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 21, 2026