Adypose Mesenchimal Stem Cell, Ligament Derived Conditined Medium, Ligament Rupture
Conditions
Keywords
adypose mesenchimal stem cell hypoxic culture conditioned, Ligament Rupture, ligament derived conditined medium
Brief summary
Transplantation of Allogenic Adipose Mesenchimal Stem cell in hypoxic cultur condition with Ligament- derived conitioned medium can enhance regeneration of posterior cruciate ligament rupture
Detailed description
this study is in vivo study to prove effect of transplantation of Allogenic Adipose Mesenchimal Stem cell in hypoxic cultur condition with Ligament- derived conitioned medium in regeneration of posterior cruciate ligament rupture
Interventions
BIOLOGICALadypose mesenchymal conditioned medium and ligament derived conditioned medium
rabbit with posterior cruciate ligament rupture and treated with fibrin glue mix with adypose mesenchymal stem cells in hypoxic culture and ligament derived conditioned medium
Sponsors
Gadjah Mada University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
2 Months to 12 Months
Healthy volunteers
Yes
Inclusion criteria
* white male new zealand rabbit * weight 2500 - 3000 gram
Exclusion criteria
* have no disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| tensile strength of posterior cruciate ligament | 6 weeks | measurement of tensile strength of posterior cruciate ligament |
| Thrombosite of Growth Factor - beta 1 | 6 weeks | measurement value of Thrombosite Growth Factor - beta 1 |
| basic fibroblast of growth factor | 6 weeks | measurement value of basic fibroblast of growth factor |
Countries
Indonesia
Contacts
Primary Contactsholahuddin rhatomy, MD
Outcome results
None listed