SibACCESS: Developing a Telehealth Intervention to Address Unmet Psychosocial Needs of Siblings of Children With Cancer

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04889755

Acronym

R03 CA259898

Enrollment

Registered

2021-05-17

Start date

2023-02-01

Completion date

2023-06-10

Last updated

2025-02-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Childhood Cancer, Pediatric Cancer, Posttraumatic Stress Disorder, Siblings

Brief summary

This study aims to address barriers to psychosocial care for siblings of children with cancer by piloting a group-based telehealth program for adolescent siblings of youth with cancer. The pilot trial will be preceded by a treatment development stage during which study staff will interview English- and Spanish-speaking families and psychosocial providers to assess preferences for program content, format, timing, and cultural feasibility and acceptability, while considering ideas to minimize participation barriers. Information from interviews will inform any revisions to the proposed pilot program. Then, the new SibACCESS program will be tested with a small group of families located in Massachusetts, Delaware, or Rhode Island using video-teleconferencing technology. Families will complete exit interviews to assess program acceptability and perceived benefits.

Detailed description

Background: Prolonged, complicated, and intensive pediatric cancer treatment regimens challenge and disrupt the entire family. Siblings of youth with cancer are a psychosocially at-risk and underserved group. Siblings frequently report strong negative emotions, disruptions to family life, poorer academic functioning, more school absenteeism (school-aged siblings), and riskier health behaviors and poorer health outcomes than comparisons (adult siblings). Approximately one-quarter of siblings meet diagnostic criteria for cancer-related posttraumatic stress disorders. Outcomes are worse for siblings from under-represented minority groups and those with fewer socioeconomic resources. Additionally, siblings report low social support and indicate a strong desire to connect with other siblings. The need for sibling support is well established, as outlined in the recently developed evidence- and consensus-based Standards for Psychosocial Care for Children with Cancer and Their Families. Unfortunately, the Sibling Standard is among those least likely to be met within pediatric oncology programs nationwide. SibACCESS Program Description: SibACCESS (Acceptance, Coping, Communication, Engagement, and Social Support) targets the proposed mechanisms of sibling difficulties. The primary goal is to increase siblings' exposure and opportunities to process cancer-related cues to decrease the onset or intensification of posttraumatic stress (PTS). Treatment targets include emotional acceptance, treatment involvement, family communication (via between-session assignments), and social support (fostered by the group format). SibACCESS is based on acceptance-based cognitive-behavioral frameworks, drawing primarily on trauma-focused CBT (TF-CBT). TF-CBT is a structured, short-term treatment that incorporates cognitive-behavioral approaches to promote recovery from trauma. It is a logical starting point for the present study for multiple reasons: (a) TF-CBT was developed specifically for children and adolescents; parent participation is recommended but not required; (b) it has been tested in a group format and using telehealth; (c) it has demonstrated effectiveness across cultural groups; and (d) it is appropriate for youth who meet diagnostic criteria for PTSD and those with sub-clinical PTS. TF-CBT has not yet been evaluated in the context of childhood cancer and may require some adaptations. Thus, SibACCESS also includes skills from Dialectical and Behavioral Therapy (i.e., self-validation of emotions, mindfulness, radical acceptance) to better address distress tolerance and acceptance of the aspects of cancer that are beyond siblings' control. SibACCESS sessions will be facilitated remotely using Zoom. The intervention includes one pre-recorded parent webinar, one brief orientation meeting (sibling and parent), seven weekly sibling group sessions, one individual sibling session, and one individual parent session. The 30-minute parent webinar will provide a program overview, psychoeducation, and brief skills training. Parents will be given discussion starter questions to facilitate communication throughout the program. Sibling group sessions are 75 minutes and will include an ice breaker, review of last week's homework (except first session), introduction of new topics, interactive practice of new skills, and assignment of home practice (except final session). Exposure to cancer-related emotions and cues will be emphasized throughout the program, including talking about cancer, confronting cancer-related thoughts and emotions, selecting several individualized cancer-related exposures, and crafting a sibling narrative.

Interventions

BEHAVIORALSibACCESS

The primary goal of the SibACCESS program is to increase siblings' exposure to and opportunity to process cancer-related cues to decrease onset or intensification of posttraumatic stress. The program is focused on siblings, with a brief parent education component. Parents will receive psychoeducation and brief skills training to support siblings enrolled in the program. Siblings will participate in 7 group sessions and one individual session in which they will learn skills and strategies to confront information about cancer and tolerate uncomfortable thoughts and feelings related to cancer, and thereby reduce avoidance of cancer-related emotions.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

SUPPORTIVE_CARE

Masking

NONE

Intervention model description

Parent Pre-session: Webinar on Supporting Siblings Session 1 (Sibling Group): Program Introduction Session 2 (Sibling Group): Understanding Emotions Session 3 (Sibling Group): Adaptive Thinking Session 4 (Sibling Group): Sitting with Emotions Session 5 (Sibling Group): Avoidance vs. Sitting with Emotions Sessions 6 (Sibling Individual): Telling Your Story Session 7 (Sibling Group): Keeping up with Skills Session 8 (Parent Individual): Parent/caregiver Check-In Session 9 (Sibling Group): Wrap-Up

Eligibility

Sex/Gender

ALL

Age

12 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* 2 or more children in the family (i.e., child with cancer and \>1 sibling) * Sibling(s) and child with cancer each under the age of 18 at the time of cancer diagnosis * Sibling(s) can be biologically-related, step-siblings, foster-siblings, or adopted-siblings * Parent and sibling(s) fluent in English * Sibling(s) 12-17 years of age * Sibling report of at least mild posttraumatic stress (score \>11 on the Child Posttraumatic Stress Scale for DSM-5) * Child with cancer must have received cancer diagnosis at least 3 months prior to the family's enrollment in the study

Exclusion criteria

* A cognitive impairment that would interfere with pilot program and interview completion (as reported by parent) * Bereavement * Significant externalizing behaviors that would interfere with group participation (as reported by parent)

Design outcomes

Primary

Measure	Time frame	Description
Child Posttraumatic Stress Disorder Symptom Scale for DSM-5	Within 2 weeks post-intervention, data were collected over a period of up to 4 weeks	The Child PTSD Symptom Scale for DSM-5 (CPSS-V) \[citation\] is a 27-item measure of posttraumatic stress. Strong test-retest reliability, internal consistency, and convergent validity with other child PTSD measures have been established. This survey was administered only to sibling participants. Measure was scored by a total summation, scores may range from 0 to 80. \*Higher scores reflect higher levels of post-traumatic stress symptoms

Secondary

Measure	Time frame	Description
Sibling Perception Questionnaire (SPQ)	Within 2 weeks post-intervention, data were collected over a period of up to 4 weeks	The Sibling Perception Questionnaire (SPQ) evaluates group interventions for siblings and parents designed to increase sibling understanding of and adjustment to chronic illness and developmental disability (CI/DD). Present measure was adapted from Sahler & Carpenter (1989) and Lobato & Kao (2002) versions to reflect cancer-related topics and create a parent-report version. Siblings and parents completed Sibling-report and Parent-report versions respectively. Measure was scored by a total summation, scores may range from 18 to 72. \*Higher scores reflect more negative sibling adjustment
Coping Self-efficacy Scale	Within 2 weeks post-intervention, data were collected over a period of up to 4 weeks	The Coping self-efficacy scale (Chesney et. al, 2006) was used to assess participants' confidence in performing coping behaviors when faced with life challenges. This measure was only used with sibling participants. Measure was scored by a total summation, scores may range from 0 to 260. \*Higher scores reflect higher levels of coping self-efficacy
Emotional Avoidance Strategy Inventory For Adolescents	Within 2 weeks post-intervention, data were collected over a period of up to 4 weeks	The Emotional Avoidance Strategy Inventory for Adolescents (Kennedy & Ehrenreich-May, 2017) is a 17-item measure of emotional avoidance with acceptable psychometrics. Measure was scored by a total summation, scores may range from 0-68.
Strengths & Difficulties Questionnaire (SDQ)	Within 2 weeks post-intervention, data were collected over a period of up to 4 weeks	The Strengths & Difficulties Questionnaire (Goodman, 1997) is a 25-item measure of children's psychosocial adjustment. It has five scales: Emotional Symptoms, Conduct Symptoms, Hyperactivity/ Inattention Symptoms, Peer Relationship Problems, and Prosocial Behavior. Adapted versions were given to sibling (self-report) and parent (parent-report) participants. Measure was scored by a total summation reflecting total child difficulties, scores may range from 0-40. \*Higher scores reflect worse child difficulties
Sibling Cancer Needs Inventory (SCNI)	Within 2 weeks post-intervention, data were collected over a period of up to 4 weeks	The Sibling Cancer Needs Inventory (SCNI) (Patterson et. al, 2014) is a 45 item measure that assesses psychosocial needs of siblings are established to assist in the provision of appropriate support. This survey was administered only to sibling participants. The overall SCNI score are determined by summing the responses to all items, giving a possible range of SCNI scores from 45 to 180. \*Higher scores reflect higher sibling psychosocial needs
Acceptability of Program	Within 2 weeks post-intervention, data were collected over a period of up to 4 weeks	Based from the Client Satisfaction Questionnaire (Roberts et. el, 1984), this measure assesses participants general acceptability of the SibACCESS intervention. Measure was scored by a total summation, scores may range from 0 to 52. \*Higher scores reflect higher levels of acceptability
Perceived Filial Self-Efficacy Scale	Within 2 weeks post-intervention, data were collected over a period of up to 4 weeks	The Perceived Filial Self-Efficacy Scale (PFSES) (Caprara et. al, 2004) is a 16-item measure that assess efficacy beliefs that family members hold about their role as spouse, parent, and child, as well as about the functioning of family as a holistic system. This survey was administered only to sibling participants. Measure was scored by a total summation, scores may range from 16 to 112. \*Higher scores reflect better efficacy beliefs

Countries

United States

Participant flow

Participants by arm

Arm	Count
SibACCESS (Sibling Participants) This is a single-arm trial of a group-based, posttraumatic stress intervention for adolescent siblings of children with cancer. The intervention includes a parent educational webinar, seven group sibling sessions, one individual parent session, and one individual sibling session. SibACCESS: The primary goal of the SibACCESS program is to increase siblings' exposure to and opportunity to process cancer-related cues to decrease onset or intensification of posttraumatic stress. The program is focused on siblings, with a brief parent education component. Parents will receive psychoeducation and brief skills training to support siblings enrolled in the program. Siblings will participate in 7 group sessions and one individual session in which they will learn skills and strategies to confront information about cancer and tolerate uncomfortable thoughts and feelings related to cancer, and thereby reduce avoidance of cancer-related emotions.	3
SibACCESS (Parent Participants) This is a single-arm trial of a group-based, posttraumatic stress intervention for adolescent siblings of children with cancer. The intervention includes a parent educational webinar, seven group sibling sessions, one individual parent session, and one individual sibling session. SibACCESS: The primary goal of the SibACCESS program is to increase siblings' exposure to and opportunity to process cancer-related cues to decrease onset or intensification of posttraumatic stress. The program is focused on siblings, with a brief parent education component. Parents will receive psychoeducation and brief skills training to support siblings enrolled in the program. Siblings will participate in 7 group sessions and one individual session in which they will learn skills and strategies to confront information about cancer and tolerate uncomfortable thoughts and feelings related to cancer, and thereby reduce avoidance of cancer-related emotions.	3
Total	6

Baseline characteristics

Characteristic	SibACCESS (Sibling Participants)	Total	SibACCESS (Parent Participants)
Age, Categorical <=18 years	3 Participants	3 Participants	0 Participants
Age, Categorical >=65 years	0 Participants	0 Participants	0 Participants
Age, Categorical Between 18 and 65 years	0 Participants	3 Participants	3 Participants
Age, Continuous	14.0 Years STANDARD_DEVIATION 1	27.7 Years STANDARD_DEVIATION 15.6	41.3 Years STANDARD_DEVIATION 7
Child PTSD Symptom Scale for DSM-5	12.7 units on a scale STANDARD_DEVIATION 4.7	12.7 units on a scale STANDARD_DEVIATION 4.7	—
Coping self-efficacy scale	173 units on a scale STANDARD_DEVIATION 49	173 units on a scale STANDARD_DEVIATION 49	—
Emotional Avoidance Strategy Inventory For Adolescents	24 units on a scale STANDARD_DEVIATION 16.8	24 units on a scale STANDARD_DEVIATION 16.8	—
Ethnicity (NIH/OMB) Hispanic or Latino	1 Participants	1 Participants	0 Participants
Ethnicity (NIH/OMB) Not Hispanic or Latino	2 Participants	5 Participants	3 Participants
Ethnicity (NIH/OMB) Unknown or Not Reported	0 Participants	0 Participants	0 Participants
Perceived Filial Self-Efficacy Scale	53.3 units on a scale STANDARD_DEVIATION 19	53.3 units on a scale STANDARD_DEVIATION 19	—
Race (NIH/OMB) American Indian or Alaska Native	0 Participants	0 Participants	0 Participants
Race (NIH/OMB) Asian	0 Participants	0 Participants	0 Participants
Race (NIH/OMB) Black or African American	0 Participants	1 Participants	1 Participants
Race (NIH/OMB) More than one race	1 Participants	1 Participants	0 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants	0 Participants	0 Participants
Race (NIH/OMB) Unknown or Not Reported	0 Participants	0 Participants	0 Participants
Race (NIH/OMB) White	2 Participants	4 Participants	2 Participants
Region of Enrollment United States	3 participants	6 participants	3 participants
Sex: Female, Male Female	0 Participants	2 Participants	2 Participants
Sex: Female, Male Male	3 Participants	4 Participants	1 Participants
Sibling Cancer Needs Inventory (SCNI)	67.3 units on a scale STANDARD_DEVIATION 11.6	67.3 units on a scale STANDARD_DEVIATION 11.6	—
Sibling Perception Questionnaire (SPQ)	25 units on a scale STANDARD_DEVIATION 11.3	30 units on a scale STANDARD_DEVIATION 10.3	35 units on a scale STANDARD_DEVIATION 7.8
Strengths & Difficulties Questionnaire (SDQ)	16.3 units on a scale STANDARD_DEVIATION 5.9	17.8 units on a scale STANDARD_DEVIATION 4.1	19.3 units on a scale STANDARD_DEVIATION 1.2

Adverse events

Event type	EG000 affected / at risk	EG001 affected / at risk
deaths Total, all-cause mortality	0 / 3	0 / 3
other Total, other adverse events	0 / 3	0 / 3
serious Total, serious adverse events	0 / 3	0 / 3

Outcome results

Primary

Child Posttraumatic Stress Disorder Symptom Scale for DSM-5

The Child PTSD Symptom Scale for DSM-5 (CPSS-V) \[citation\] is a 27-item measure of posttraumatic stress. Strong test-retest reliability, internal consistency, and convergent validity with other child PTSD measures have been established. This survey was administered only to sibling participants. Measure was scored by a total summation, scores may range from 0 to 80. \*Higher scores reflect higher levels of post-traumatic stress symptoms