Understand the Association Between Peritoneal Dialysis Status and Gene Polymorphisms of VEGF and KDR

Gene Polymorphisms of VEGF and KDR Are Associated With Initial High Transport Status in Peritoneal Dialysis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04888065

Enrollment

200

Registered

2021-05-17

Start date

2018-05-10

Completion date

2020-12-30

Last updated

2021-05-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peritoneal Dialysis

Brief summary

Peritoneal dialysis (PD) is an effective and successful way of renal replacement therapy. The initial transport status is related to distribution of blood vessels and micro inflammation state in peritoneum before PD. Vascular endothelial growth factor(VEGF) and its receptor, kinase insert domain containing receptor(KDR) may play important roles on initial transport status. This study include 200 PD patients from Renji Hospital in Shanghai, China. According to the 4h D/P Cr within three months of starting PD therapy, we analyzed the association between the polymorphisms of VEGF and KDR and initial peritoneal transport property.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

1. Patients are Han Chinese; 2. Patients prepare for dialysis in our center, and start PD within 3 months after abdominal catheterization; 3. Patients successfully complete the first peritoneal equilibration test(PET); 4. Follow up regularly in our PD center.

Exclusion criteria

1. Patients from hemodialysis to peritoneal dialysis; 2. Patients who need peritoneal dialysis due to transplant-renal loss;

Design outcomes

Primary

Measure	Time frame	Description
The relationship between VEGF and KDR Gene polymorphisms and initial transport status in peritoneal dialysis	For each patient, the outcome would be cross sectional measured at the time the patient does first/initial Peritoneal Equilibration Test. The data collection time period of the study is within 3 months.	According to the 4h dialysate over plasma ratio for creatinine （D/P Cr） within three months of starting PD therapy, patients were divided into high transport(H) or high average transport(HA) (H/HA) group and low transport(L) or low average transport(LA) (L/LA) group. Gene polymorphisms of selected VEGF and KDR SNPs were analyzed using extracted blood DNA from these patients. We aimed to investigate the relationship between VEGF and KDR gene polymorphisms and initial peritoneal transport property.

Countries

China

Outcome results