Topical Agents Containing Magnesium Sulfate & Wound Healing in the Rat Model

The Effect of Topical Agents in Cream Formations Containing Magnesium Sulfate on Wound Healing in the Rat Model

Status

UNKNOWN

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04886882

Enrollment

Registered

2021-05-14

Start date

2021-03-22

Completion date

2021-07-01

Last updated

2021-05-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Wound Heal

Keywords

magnesium sulphate, wound healing rat model, hydroxyproline

Brief summary

An experimental study examining wound healing in 5 different groups on 30 rats.

Detailed description

Magnesium topically increases collagen synthesis and angiogenesis, providing faster and higher quality wound healing. In addition, with its analgesic effect, it will also eliminate the pain sensation caused by the wound and increase the quality of life of the patient whose skin integrity is impaired.

Interventions

OTHERplacebo comparator

solution containing 0.9 % sodium chlorine

OTHERsham comparator

vaseline, beeswax,polyglyceryl-3 diisostearate, sorbitan caprylate, propandiol,benzoic acid, glycerin, water

OTHERExperimental drug 1

A cream containing 10 % MgSO4.vaseline, beeswaxpolyglyceryl-3 diisostearate, sorbitan caprylate, propandiol,benzoic acid, glycerin, water

OTHERExperimental drug 2

A cream containing 10 % MgSO4.vaseline, beeswax,polyglyceryl-3 diisostearate, sorbitan caprylate, propandiol,benzoic acid, glycerin, water

DRUGCentella asiatica

A cream containing Centella asiatica

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Caregiver)

Eligibility

Sex/Gender

FEMALE

Age

8 Weeks to 12 Weeks

Healthy volunteers

Yes

Inclusion criteria

* healthy rats between ages of 8- 12 weeks

Exclusion criteria

* weight loss of more than 15% of body weight

Design outcomes

Primary

Measure	Time frame	Description
7th day evaluation	7th day	Histopathological evaluation of wound healing comparing with the rate of vascular endothelial growth factor (VEGF), transforming growth factor (TGF-beta) and hydroxyproline at immunohistochemical staining with biopsy on the 7th day.

Secondary

Measure	Time frame	Description
15th day evaluation	15th day	Histopathological evaluation of wound healing comparing with the rate of VEGF, TGF-beta and hydroxyproline at immunohistochemical staining with biopsy on the 15th day.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026