Caffeine and the Autonomic Nervous System

Impact of Caffeine Consumption on Markers of the Autonomic Nervous System

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04886869

Enrollment

Registered

2021-05-14

Start date

2021-04-01

Completion date

2021-06-30

Last updated

2026-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autonomic Nervous System Imbalance

Brief summary

Caffeine consumption has been linked to dysfunction of the autonomic nervous system. In this study the investigators analyze the effects of caffeine containing drinks (including energy drinks and coffee) on ECG based parameters of the autonomic nervous system.

Interventions

DIETARY_SUPPLEMENTcaffeine

oral consumption

Study design

Allocation

NON_RANDOMIZED

Intervention model

SEQUENTIAL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* healthy individuals * \> 18 years

Exclusion criteria

* known cardiovascular disease * other diseases which may influence the autonomic nervous system * medication which may influence the autonomic nervous system * prior caffeine consumption (\<24 hours)

Design outcomes

Primary

Measure	Time frame	Description
Heart rate (HR)	2 hours	ECG-based analysis of heart rate (beats per minute)

Secondary

Measure	Time frame	Description
Periodic repolarization dynamics (PRD)	2 hours	ECG-based analysis of repolarization instability (deg²)

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 7, 2026