Vitamin C Deficiency
Conditions
Brief summary
To evaluate the difference between vitamin C in the form of oral liposomes and general vitamin C in a fixed period of time in plasma and urine.
Detailed description
we recruited 11 healthy subjects and adopted a cross-over test. the subjects need to take 3 tests during trail. After each test was completed, a washout period of 14 days was required before the next test start. The subjects were informed to consume one sachet vitamin C without liposome, liposomal process A vitamin C, or liposomal process B vitamin C (Double Nutri™) every test, and vitamin C concentration was measured at baseline (0 hours), 0.5, 1, 2, 3, 4, and 8 hours after taking test sample.
Interventions
DIETARY_SUPPLEMENTvitamin C without liposome
subjects need to take 3 tests during trail. After each test was completed, a washout period of 14 days was required before the next test start
DIETARY_SUPPLEMENTliposomal process A vitamin C
subjects need to take 3 tests during trail. After each test was completed, a washout period of 14 days was required before the next test start
DIETARY_SUPPLEMENTliposomal process B vitamin C (Double Nutri™)
subjects need to take 3 tests during trail. After each test was completed, a washout period of 14 days was required before the next test start
Sponsors
TCI Co., Ltd.
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
1. Adults between 20-60 years old, 2. No heart, liver, kidney, endocrine and major organic diseases
Exclusion criteria
1. Renal insufficiency and dialysis 2. Cancer 3. Underweight (BMI≦17) or obese (BMI≧27), 4. Take chronic disease drugs, 5. Blood pressure systolic blood pressure ≧130 mmHg or diastolic blood pressure ≧85 mmHg, 6. Too high fasting blood glucose ≧ 100 mg/dL, 7. Triglyceride ≧ 150 mg/dL,Total cholesterol ≧ 200 mg/dL, 8. Have a history of vitamin C allergy, 9. People with mental illness, 10. Pregnant or breastfeeding women, 11. Hematosis, 12. Kidney stones, 13. Long-term vitamin C supplements (at least 200 mg per day for more than one month)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| vitamin c detection | at 8 hours after taking test sample | vitamin c was assessed by Ascorbic Acid Colorimetric Assay Kit II |
| The change of Triglyceride | at 8 hours after taking test sample | Venous blood was sampled to measure concentrations of Triglyceride |
| The change of body mass index (BMI) | Time 0, 0.5, 1, 2, 3, 4, and 8 hours after taking test sample | BMI is a measurement of a person's leanness or corpulence based on their height and weight, and is intended to quantify tissue mass.The body mass index (BMI, kg/m\^2) and body mass (kg) were assessed by InBody770. |
| The change of aspartate aminotransferase | at 8 hours after taking test sample | Venous blood was sampled to measure concentrations of aspartate aminotransferase |
| The change of alanine aminotransferase | at 8 hours after taking test sample | Venous blood was sampled to measure concentrations of alanine aminotransferase |
| The change of creatine | at 8 hours after taking test sample | Venous blood was sampled to measure concentrations of creatine |
Countries
Taiwan
Outcome results
None listed