Dyslipidemias
Conditions
Brief summary
In order to study the effect of resveratrol on the improvement of lipid and uric acid metabolism, randomized intervention trials were conducted to compare the effects of resveratrol on the improvement of lipid and uric acid metabolism in different dose groups. To explore the best dose of resveratrol for the prevention and treatment of metabolic diseases provide an important scientific basis.
Detailed description
In order to study the effect of resveratrol on the improvement of lipid and uric acid metabolism, randomized controlled trials were conducted to enrolled 160 patients with dyslipidemia. The subjects were divided into 0 mg / d, 100 mg / d, 300 mg / d, 600 mg/ d four dose groups, intervention for 8 weeks, comparing different doses of resveratrol on lipid and uric acid metabolism. To explore the best dose of resveratrol for the prevention and treatment of metabolic diseases provide an important scientific basis.
Interventions
DRUGMega Resveratrol® capsules
Subjects were orally administered Mega Resveratrol® capsules daily for 8 weeks.
DRUGMega Resveratrol® Placebo capsules
Mega Resveratrol® Placebo capsules
Sponsors
Sun Yat-sen University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
35 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Dyslipidemia * The age between 35 and 70 years old
Exclusion criteria
* Intake of any medicine that affect lipid metabolism currently or in the preceding 6 months * Dietary supplementation with phytochemicals including resveratrol in the preceding 3 months * History of acute or chronic infectious disease, autoimmune disease, cancer, traumatic injury, or surgery in the preceding 1 month * History of severe chronic disease including AS and CVD, liver or renal dysfunction, and lactation or pregnancy * Pregnant woman and Breast Feeding Women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect of resveratrol on lipid profile in patients with dyslipidemia | Change from Baseline to 4 weeks and 8 weeks | Lipid profile in serum will be measured, mainly including TC, TG, LDL-C and HDL-C, by automatic biochemical analyzer. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effect of resveratrol on uric acid and xanthine oxidase in patients with dyslipidemia | Change from Baseline to 4 weeks and 8 weeks | Uric acid concentration and xanthine oxidase activity will be measured by automatic biochemical analyzer and commercial kits, respectively. |
Countries
China
Outcome results
None listed